Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jin | - |
dc.contributor.author | Cho, Joon-Yong | - |
dc.contributor.author | Kim, Won-Kyu | - |
dc.date.accessioned | 2022-07-16T04:31:25Z | - |
dc.date.available | 2022-07-16T04:31:25Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159842 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effects of exercise (EX) and Korean red ginseng (KRG) on inflammation mechanism in aging model rats with diet-induced atherosclerosis. MATERIALS/METHODS: Forty-eight male Sprague-Dawley rats were divided into 6 groups: Young control (Y-C), Aging control (A-C), A-C with HFD (AHF), AHF with EX (AHF-EX), AHF-EX with KRG (AHF-EX+RG), and AHF with KRG (AHF-RG). Aging was induced by D-gal (100mg/kg) and atherosclerosis was induced by HFD (60% fat) for 9 weeks. The experimental rats were performed swimming (60 min/day, 5 days/week) and supplied KRG orally (dose of 200 mg/kg) for 8 weeks. All rat aorta samples were harvested for biochemical and immunohistochemical analyses. REULTS: The EX and KRG supplementation significantly inhibited body weight and levels of TC, TG, LDL-C, and enhance of HDL-C compared with untreated AHF groups. AHF-EX, AHF-EX+RG, and AHF-RG group showed a decreased plasma CRP and increase plasma NO activities compared to AHF group. In addition, these groups revealed reduced 4-HNE, NF-kB, TNF-a, IL-6, COX-2, ICAM-1, VCAM-1 and enhanced eNOS expression in the aorta. CONCLUSION: These results suggest that EX alone, KRG alone, and combined treatment of EX and KRG may be an effective anti-inflammatory therapeutic for the atherosclerosis, possibly acting via the decreased of CRP and pro-inflammation proteins and the increased NO and eNOS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.title | Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Won-Kyu | - |
dc.identifier.doi | 10.4162/nrp.2014.8.3.284 | - |
dc.identifier.scopusid | 2-s2.0-84902842972 | - |
dc.identifier.wosid | 000336774000008 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.8, no.3, pp.284 - 291 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 284 | - |
dc.citation.endPage | 291 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001878985 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | VASCULAR SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ALPHA-LIPOIC ACID | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BODY-COMPOSITION | - |
dc.subject.keywordPlus | ENDOTHELIAL FUNCTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DISEASE RISK | - |
dc.subject.keywordAuthor | Korea red ginseng | - |
dc.subject.keywordAuthor | exercise | - |
dc.subject.keywordAuthor | lipid profiles | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | atherosclerosis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.