Experimental evaluation of the effect of a modified port-location mode on the performance of a three-zone simulated moving-bed process for the separation of valine and isoleucine
- Authors
- Park, Chanhun; Nam, Hee-Geun; Kim, Pung-Ho; Mun, Sungyong
- Issue Date
- Jun-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Continuous separation; Process optimization; Simulated moving bed; Valine
- Citation
- JOURNAL OF SEPARATION SCIENCE, v.37, no.11, pp.1215 - 1221
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF SEPARATION SCIENCE
- Volume
- 37
- Number
- 11
- Start Page
- 1215
- End Page
- 1221
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159847
- DOI
- 10.1002/jssc.201400089
- ISSN
- 1615-9306
- Abstract
- The removal of isoleucine from valine has been a key issue in the stage of valine crystallization, which is the final step in the valine production process in industry. To address this issue, a three-zone simulated moving-bed (SMB) process for the separation of valine and isoleucine has been developed previously. However, the previous process, which was based on a classical port-location mode, had some limitations in throughput and valine product concentration. In this study, a three-zone SMB process based on a modified port-location mode was applied to the separation of valine and isoleucine for the purpose of making a marked improvement in throughput and valine product concentration. Computer simulations and a lab-scale process experiment showed that the modified three-zone SMB for valine separation led to >65% higher throughput and >160% higher valine concentration compared to the previous three-zone SMB for the same separation.
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