Clinical outcomes of transjugular intrahepatic portosystemic shunt for portal hypertension: Korean multicenter real-practice data

Abstract

Background/Aims: This retrospective study assessed the clinical outcome of a transjugular intrahepaticportosystemic shunt (TIPS) procedure for managing portal hypertension in Koreans with liver cirrhosis. Methods: Between January 2003 and July 2013, 230 patients received a TIPS in 13 university-based hospitals. Results: Of the 229 (99.6%) patients who successfully underwent TIPS placement, 142 received a TIPS for varicealbleeding, 84 for refractory ascites, and 3 for other indications. The follow-up period was 24.9±30.2 months (mean±SD),74.7% of the stents were covered, and the primary patency rate at the 1-year follow-up was 78.7%. Hemorrhageoccurred in 30 (21.1%) patients during follow-up; of these, 28 (93.3%) cases of rebleeding were associated with stentdysfunction. Fifty-four (23.6%) patients developed new hepatic encephalopathy, and most of these patients weresuccessfully managed conservatively. The cumulative survival rates at 1, 6, 12, and 24 months were 87.5%, 75.0%,66.8%, and 57.5%, respectively. A high Model for End-Stage Liver Disease (MELD) score was significantly associatedwith the risk of death within the first month after receiving a TIPS (P=0.018). Old age (P<0.001), indication for a TIPS(ascites vs. bleeding, P=0.005), low serum albumin (P<0.001), and high MELD score (P=0.006) were associated withoverall mortality. Conclusions: A high MELD score was found to be significantly associated with early and overall mortality rate in TIPSpatients. Determining the appropriate indication is warranted to improve survival in these patients.