Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents
DC Field | Value | Language |
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dc.contributor.author | Park, Meerim | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Kang, Hae-Ryong | - |
dc.contributor.author | Lee, Ji Won | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Park, Kyung Duk | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Baek, Hee Jo | - |
dc.contributor.author | Kook, Hoon | - |
dc.contributor.author | Hwang, Tai Ju | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Chung, Nack-Gyun | - |
dc.contributor.author | Cho, Bin | - |
dc.contributor.author | Kim, Hack-Ki | - |
dc.contributor.author | Lee, Soo Hyun | - |
dc.contributor.author | Yoo, Keon Hee | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.contributor.author | Koh, Kyung Nam | - |
dc.contributor.author | Im, Ho Joon | - |
dc.contributor.author | Seo, Jong Jin | - |
dc.contributor.author | Park, Jun Eun | - |
dc.contributor.author | Lim, Yeon Jung | - |
dc.contributor.author | Lyu, Chuhl Joo | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Hah, Jeong Ok | - |
dc.date.accessioned | 2022-07-16T05:40:33Z | - |
dc.date.available | 2022-07-16T05:40:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1397-3142 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160494 | - |
dc.description.abstract | This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n=24), iBMFS, (n=16), and primary immune deficiency/inherited metabolic disorder (n=25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II-IV graft-versus-host disease was 32.3%. At a median follow-up of 71months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91x10(5)/kg of infused CD34+ cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p=0.04) and OS (p=0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1111/petr.12213 | - |
dc.identifier.scopusid | 2-s2.0-84893818614 | - |
dc.identifier.wosid | 000330740100022 | - |
dc.identifier.bibliographicCitation | PEDIATRIC TRANSPLANTATION, v.18, no.2, pp.221 - 229 | - |
dc.relation.isPartOf | PEDIATRIC TRANSPLANTATION | - |
dc.citation.title | PEDIATRIC TRANSPLANTATION | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 229 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | SEVERE APLASTIC-ANEMIA | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | TOTAL-BODY IRRADIATION | - |
dc.subject.keywordPlus | ANTI-THYMOCYTE GLOBULIN | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | FANCONI-ANEMIA | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | PEDIATRIC-PATIENTS | - |
dc.subject.keywordPlus | ANTITHYMOCYTE GLOBULIN | - |
dc.subject.keywordAuthor | unrelated cord blood transplantation | - |
dc.subject.keywordAuthor | non-malignant disease | - |
dc.subject.keywordAuthor | children | - |
dc.subject.keywordAuthor | adolescents | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/petr.12213 | - |
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