Interleukin-18 as an efficient marker for remission and follow-up in patients with inactive adult-onset Still's disease
DC Field | Value | Language |
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dc.contributor.author | Jung, K-H | - |
dc.contributor.author | Kim, J-J | - |
dc.contributor.author | Lee, J-S | - |
dc.contributor.author | Park, W. | - |
dc.contributor.author | Kim, T-H | - |
dc.contributor.author | Jun, J-B | - |
dc.contributor.author | Yoo, D. H. | - |
dc.date.accessioned | 2022-07-16T05:45:07Z | - |
dc.date.available | 2022-07-16T05:45:07Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0300-9742 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160533 | - |
dc.description.abstract | Objectives: Diagnosis of adult-onset Still's disease (AOSD) is difficult because of a lack of pathognomonic findings and markers. The aim of this study was to investigate the efficacy of interleukin (M)-18 and free IL-18 in the diagnosis and follow-up of patients with AOSD. Method: Levels of inflammatory cytokines, IL-18, IL-18 binding protein (IL-18BP), and free IL-18 were compared in 80 AOSD patients and 90 controls. The AOSD patients were divided into active and inactive groups according to disease activity, and the inactive patients were subdivided into a remission subgroup and a low disease activity subgroup. We compared erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, IL-18, and free IL-18 as disease activity markers in the AOSD patients. Serial serum levels of activity markers were measured in 52 of the 80 AOSD patients at 3- to 6-month intervals. Results:There were significantly higher levels of IL-18 and free IL-18 in the AOSD patients than in the controls. IL-18 and free IL-18 were significantly higher in the active group than the inactive group (p < 0.001 for all). Unlike other activity markers, IL-18 and free IL-18 levels in the low disease activity subgroup were significantly higher than those in the remission subgroup within the inactive group (p = 0.004 and 0.005, respectively). During serial follow-up, ferritin and IL-18 showed a significant decrease in the responder and remission subgroup. Conclusions: IL-18 might be an efficient marker for diagnosis and follow-up of AOSD and might also be a useful predictor of remission, especially in clinically inactive patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Interleukin-18 as an efficient marker for remission and follow-up in patients with inactive adult-onset Still's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, T-H | - |
dc.contributor.affiliatedAuthor | Jun, J-B | - |
dc.contributor.affiliatedAuthor | Yoo, D. H. | - |
dc.identifier.doi | 10.3109/03009742.2013.824023 | - |
dc.identifier.scopusid | 2-s2.0-84895749354 | - |
dc.identifier.wosid | 000333784800011 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v.43, no.2, pp.162 - 169 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 169 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | IL-18 | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/03009742.2013.824023 | - |
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