Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Insights into the Role of Follicular Helper T Cells in Autoimmunity

Full metadata record
DC Field Value Language
dc.contributor.authorPark, Hong-Jai-
dc.contributor.authorKim, Do-Hyun-
dc.contributor.authorLim, Sang-Ho-
dc.contributor.authorKim, Won-Ju-
dc.contributor.authorYoun, Jee hee-
dc.contributor.authorChoi, Youn-Soo-
dc.contributor.authorChoi, Je Min-
dc.date.accessioned2022-07-16T06:05:42Z-
dc.date.available2022-07-16T06:05:42Z-
dc.date.created2021-05-13-
dc.date.issued2014-02-
dc.identifier.issn1598-2629-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160681-
dc.description.abstractFollicular helper T (TFH) cells are recently highlighted as their crucial role for humoral immunity to infection as well as their abnormal control to induce autoimmune disease. During an infection, naïve T cells are differentiating into TFH cells which mediate memory B cells and long-lived plasma cells in germinal center (GC). TFH cells are characterized by their expression of master regulator, Bcl-6, and chemokine receptor, CXCR5, which are essential for the migration of T cells into the B cell follicle. Within the follicle, crosstalk occurs between B cells and TFH cells, leading to class switch recombination and affinity maturation. Various signaling molecules, including cytokines, surface molecules, and transcription factors are involved in TFH cell differentiation. IL-6 and IL-21 cytokine- mediated STAT signaling pathways, including STAT1 and STAT3, are crucial for inducing Bcl-6 expression and TFH cell differentiation. TFH cells express important surface molecules such as ICOS, PD-1, IL-21, BTLA, SAP and CD40L for mediating the interaction between T and B cells. Recently, two types of microRNA (miRNA) were found to be involved in the regulation of TFH cells. The miR-17-92 cluster induces Bcl-6 and TFH cell differentiation, whereas miR-10a negatively regulates Bcl-6 expression in T cells. In addition, follicular regulatory T (TFR) cells are studied as thymus-derived CXCR5⁺PD-1⁺Foxp3⁺ Treg cells that play a significant role in limiting the GC response. Regulation of TFH cell differentiation and the GC reaction via miRNA and TFR cells could be important regulatory mechanisms for maintaining immune tolerance and preventing autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Here, we review recent studies on the various factors that affect TFH cell differentiation, and the role of TFH cells in autoimmune diseases.-
dc.language영어-
dc.language.isoen-
dc.publisher대한면역학회-
dc.titleInsights into the Role of Follicular Helper T Cells in Autoimmunity-
dc.typeArticle-
dc.contributor.affiliatedAuthorYoun, Jee hee-
dc.contributor.affiliatedAuthorChoi, Je Min-
dc.identifier.doi10.4110/in.2014.14.1.21-
dc.identifier.bibliographicCitationImmune Network, v.14, no.1, pp.21 - 29-
dc.relation.isPartOfImmune Network-
dc.citation.titleImmune Network-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage21-
dc.citation.endPage29-
dc.type.rimsART-
dc.identifier.kciidART001916847-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.subject.keywordAuthorFollicular helper T cells-
dc.subject.keywordAuthorGerminal Center-
dc.subject.keywordAuthorFollicular regulatory T cells-
dc.subject.keywordAuthorCytokines-
dc.subject.keywordAuthorAutoimmunity-
Files in This Item
Appears in
Collections
서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
서울 의과대학 > 서울 해부·세포생물학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Je Min photo

Choi, Je Min
COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)
Read more

Altmetrics

Total Views & Downloads

BROWSE