Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
- Authors
- Ye, Byoung Seok; Seo, Sang Won; Kim, Chi Hun; Jeon, Seun; Kim, Geon Ha; Noh, Young; Cho, Hanna; Yoon, Cindy W.; Kim, Hee Jin; Jang, Eun Young; Lee, Jeongmin; Kim, Jung-Hyun; Chin, Juhee; Lee, Jong Min; Kim, Jeong-Hun; Seong, Joon-kyung; Kim, Chang-Hun; Choe, Yearn Seong; Lee, Kyung Han; Na, Duk L.
- Issue Date
- Feb-2014
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Mild cognitive impairment; Alzheimer' s disease; Pittsburgh compound B; Cortical thickness; Hippocampus
- Citation
- NEUROBIOLOGY OF AGING, v.35, no.2, pp.291 - 300
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROBIOLOGY OF AGING
- Volume
- 35
- Number
- 2
- Start Page
- 291
- End Page
- 300
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160714
- DOI
- 10.1016/j.neurobiolaging.2013.08.017
- ISSN
- 0197-4580
- Abstract
- Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N = 16) and PiB (+) (N = 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.
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