Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-gamma Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Lee, Youn Jin | - |
dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Lee, Jin-A | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.date.accessioned | 2022-07-16T06:23:59Z | - |
dc.date.available | 2022-07-16T06:23:59Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160883 | - |
dc.description.abstract | Purpose: We tested whether rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-gamma agonist, can restore alveolar development and vascular growth in a rat model of bronchopulmonary dysplasia (BPD). Materials and Methods: A rat model of BPD was induced through intra-amniotic delivery of lipopolysaccharide (LPS) and postnatal hyperoxia (80% for 7 days). RGZ (3 mg/kg/d, i.p.) or vehicle was given daily to rat pups for 14 days. This model included four experimental groups: No BPD+vehicle (V), No BPD+RGZ, BPD+V, and BPD+RGZ. On D14, alveolarization, lung vascular density, and right ventricular hypertrophy (RVH) were evaluated. Results: Morphometric analysis revealed that the BPD+RGZ group had significantly smaller and more complex airspaces and larger alveolar surface area than the BPD+V group. The BPD+RGZ group had significantly greater pulmonary vascular density than the BPD+V group. Western blot analysis revealed that significantly decreased levels of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 by the combined exposure to intra-amniotic LPS and postnatal hyperoxia were restored by the RGZ treatment RVH was significantly lesser in the BPD+RGZ group than in the BPD+V group. Conclusion: These results suggest that RGZ can restore alveolar and pulmonary vascular development and lessen pulmonary hypertension in a rat model of BPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.title | Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-gamma Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Ju | - |
dc.identifier.doi | 10.3349/ymj.2014.55.1.99 | - |
dc.identifier.scopusid | 2-s2.0-84890620046 | - |
dc.identifier.wosid | 000330142300014 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.55, no.1, pp.99 - 106 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 99 | - |
dc.citation.endPage | 106 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001834840 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | CHRONIC LUNG-DISEASE | - |
dc.subject.keywordPlus | INTRAAMNIOTIC LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | POSTNATAL HYPEROXIA | - |
dc.subject.keywordPlus | NEONATAL HYPEROXIA | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordAuthor | Bronchopulmonary dysplasia | - |
dc.subject.keywordAuthor | peroxisome proliferator-activated receptor-gamma | - |
dc.subject.keywordAuthor | rosiglitazone | - |
dc.subject.keywordAuthor | alveolarization | - |
dc.identifier.url | https://eymj.org/DOIx.php?id=10.3349/ymj.2014.55.1.99 | - |
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