Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea
DC Field | Value | Language |
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dc.contributor.author | Sohnn, Won | - |
dc.contributor.author | Lee, Oh Young | - |
dc.contributor.author | Lee, Sang Pyo | - |
dc.contributor.author | Lee, Kang Nyeong | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Lee, Hang Lak | - |
dc.contributor.author | Yoon, Byung Chul | - |
dc.contributor.author | Choi, Ho Soon | - |
dc.contributor.author | Sim, Jongmin | - |
dc.contributor.author | Jang, Ki-Seok | - |
dc.date.accessioned | 2022-07-16T06:26:56Z | - |
dc.date.available | 2022-07-16T06:26:56Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/160910 | - |
dc.description.abstract | Background. Recent studies have shown that mast cells play an important role in irritable bowel syndrome (IBS). We investigated the relationship between mast cells and the gut hormones substance P and vasoactive intestinal peptide (VIP) in irritable bowel syndrome with diarrhea (IBS-D). Methods. Colonoscopic biopsies were performed on the rectal mucosa of 43 subjects (IBS-D patients: 22, healthy volunteers: 21) diagnosed according to the Rome III criteria. Mast cells, and substance P & VIP were evaluated by quantitative immunohistology and image analysis. Mast cells were counted as tryptase-positive cells in the lamina propria, and substance P and VIP levels were expressed as percentages of total areas of staining. Results. Mast cell counts were higher in IBS-D patients than healthy volunteers (9.6 +/- 3.3 vs. 5.7 +/- 2.5/high power field (HPF), p < 0.01). Substance P was also elevated (0.11 +/- 0.08% vs. 0.03 +/- 0.02 %, p < 0.01) while VIP was only high in women with IBS-D. Mast cell counts were positively correlated with levels of substance P & VIP in women but not men (women: r = 0.625, p < 0.01 for substance P and r = 0.651, p < 0.01 for VIP). However, mast cell counts were not correlated with IBS symptoms including abdominal pain. Conclusion. Mast cells are activated leading to the raised levels of substance P & VIP in IBS-D patients. However, the correlation between mast cells and levels of substance P & VIP differs according to gender. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Oh Young | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.contributor.affiliatedAuthor | Lee, Hang Lak | - |
dc.contributor.affiliatedAuthor | Yoon, Byung Chul | - |
dc.contributor.affiliatedAuthor | Choi, Ho Soon | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Seok | - |
dc.identifier.doi | 10.3109/00365521.2013.857712 | - |
dc.identifier.scopusid | 2-s2.0-84890904617 | - |
dc.identifier.wosid | 000328948600006 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.49, no.1, pp.43 - 51 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 49 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 51 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | IMMUNE ACTIVATION | - |
dc.subject.keywordPlus | GENDER | - |
dc.subject.keywordPlus | NERVES | - |
dc.subject.keywordPlus | GUT | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROXIMITY | - |
dc.subject.keywordPlus | CORRELATE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordAuthor | irritable bowel syndrome | - |
dc.subject.keywordAuthor | mast cell | - |
dc.subject.keywordAuthor | substance P | - |
dc.subject.keywordAuthor | vasoactive intestinal peptide | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/00365521.2013.857712 | - |
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