Granulocyte-Colony Stimulating Factor Reduces Cardiomyocyte Apoptosis and Ameliorates Diastolic Dysfunction in Otsuka Long-Evans Tokushima Fatty Rats
DC Field | Value | Language |
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dc.contributor.author | Shin, Jeong Hun | - |
dc.contributor.author | Lim, Young-Hyo | - |
dc.contributor.author | Song, Yi-Sun | - |
dc.contributor.author | So, Byung-Im | - |
dc.contributor.author | Park, Jun-Young | - |
dc.contributor.author | Fang, Cheng-Hu | - |
dc.contributor.author | Lee, Yonggu | - |
dc.contributor.author | Kim, Hyuck | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.date.accessioned | 2022-07-16T06:49:39Z | - |
dc.date.available | 2022-07-16T06:49:39Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0920-3206 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161068 | - |
dc.description.abstract | Background In recent studies, granulocyte-colony stimulating factor (G-CSF) was shown to improve cardiac function in myocardial infarction and non-ischemic cardiomyopathies. The mechanisms of these beneficial effects of G-CSF in diabetic cardiomyopathy are not yet fully understood. Therefore, we investigated the mechanisms of action of G-CSF on diabetic cardiomyopathy in a rat model of type 2 diabetes. Methods Seventeen-week-old OLETF (Otsuka Long Evans Tokushima Fatty) diabetic rats and LETO (Long Evans Tokushima Otuska) rats were randomized to treatment with 5 days of G-CSF (100 μg/kg/day) or with saline. Cardiac function was evaluated by serial echocardiography performed before and 4 weeks after treatment. We measured expression of the G-CSF receptor (GCSFR) and Bcl-2, as well as the extent of apoptosis in the myocardium. Results G-CSF treatment significantly improved cardiac diastolic function in the serial echocardiography assessments. Expression of G-CSFR was down-regulated in the diabetic myocardium (0.03 ± 0.12 % vs. 1 ± 0.15 %, p < 0.05), and its expression was stimulated by G-CSF treatment (0.03 ± 0.12 % vs. 0.42 ± 0.06 %, p < 0.05). In addition, G-CSF treatment increased the expression of Bcl-2 in the diabetic myocardium (0.69 ± 0.06 % vs. 0.26 ± 0.11 %, p < 0.05), consistent with the reduced cardiomyocyte apoptosis (9.38 ± 0.67 % vs. 17.28 ± 2.16 %, p < 0.05). Conclusions Our results suggest that G-CSF might have a cardioprotective effect in diabetic cardiomyopathy through up-regulation of G-CSFR, attenuation of apoptosis by up-regulation of Bcl-2 expression, and glucose-lowering effect. Our findings support the therapeutic potential of G-CSF in diabetic cardiomyopathy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Granulocyte-Colony Stimulating Factor Reduces Cardiomyocyte Apoptosis and Ameliorates Diastolic Dysfunction in Otsuka Long-Evans Tokushima Fatty Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Jeong Hun | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hyo | - |
dc.contributor.affiliatedAuthor | Lee, Yonggu | - |
dc.contributor.affiliatedAuthor | Kim, Hyuck | - |
dc.identifier.doi | 10.1007/s10557-014-6519-8 | - |
dc.identifier.scopusid | 2-s2.0-84903770114 | - |
dc.identifier.wosid | 000338639900004 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DRUGS AND THERAPY, v.28, no.3, pp.211 - 220 | - |
dc.relation.isPartOf | CARDIOVASCULAR DRUGS AND THERAPY | - |
dc.citation.title | CARDIOVASCULAR DRUGS AND THERAPY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 220 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM-CELLS | - |
dc.subject.keywordPlus | CHRONIC HEART-FAILURE | - |
dc.subject.keywordPlus | CARDIAC-FUNCTION | - |
dc.subject.keywordPlus | G-CSF | - |
dc.subject.keywordPlus | DIABETIC CARDIOMYOPATHY | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | HYPERGLYCEMIA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Diabetic cardiomyopathy | - |
dc.subject.keywordAuthor | G-CSF | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10557-014-6519-8 | - |
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