Clinical characteristics of hemophagocytic lymphohistiocytosis following kawasaki disease: Differentiation from recurrent kawasaki disease
DC Field | Value | Language |
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dc.contributor.author | Kang, Hae-Ryong | - |
dc.contributor.author | Kwon, Yong-hoon | - |
dc.contributor.author | Yoo, Eun-Sun | - |
dc.contributor.author | Ryu, Kyung-Ha | - |
dc.contributor.author | Kim, Ji Yoon | - |
dc.contributor.author | Kim, Heung-Sik | - |
dc.contributor.author | Kim, Hwang Min | - |
dc.contributor.author | Lee, Young-Ho | - |
dc.date.accessioned | 2022-07-16T07:01:31Z | - |
dc.date.available | 2022-07-16T07:01:31Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161245 | - |
dc.description.abstract | Background: Our aim was to investigate the clinical pattern of hemophagocytic lymphohistiocytosis following Kawasaki disease (HLH-KD), to enable differentiation of HLH from recurrent or refractory KD and facilitate early diagnosis. Methods: We performed a nationwide retrospective survey and reviewed the clinical characteristics of patients with HLH-KD, including the interval between KD and HLH, clinical and laboratory findings, treatment responses, and outcomes, and compared them with historical data for both diseases. Results: Twelve patients with HLH-KD, including 5 previously reported cases, were recruited. The median age was 6.5 years (range, 9 months-14.7 years). Eight patients were male and 4 were female. The median interval between the first episode of KD and the second visit with recurrent fever was 12 days (3-22 days). Of the 12 children, 2 were initially treated with intravenous IgG (IVIG) for recurrent KD when they presented at the hospital with recurrent fever. Eventually, 10 children received chemotherapy under an HLH protocol and 2 received supportive treatment. Two patients died of combined infections during chemotherapy, 1 was lost to follow up, and 9 remain alive. The overall survival rate at 4 years was 81.1% with a median follow up of 45.1 months. Conclusion: A diagnosis of HLH-KD should be considered when symptoms similar to recurrent KD develop within 1 month of the first episode of KD. Our findings will help physicians differentiate between HLH and the recurrent form of KD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Hematology | - |
dc.title | Clinical characteristics of hemophagocytic lymphohistiocytosis following kawasaki disease: Differentiation from recurrent kawasaki disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young-Ho | - |
dc.identifier.doi | 10.5045/br.2013.48.4.254 | - |
dc.identifier.scopusid | 2-s2.0-84891044857 | - |
dc.identifier.bibliographicCitation | Blood Research, v.48, no.4, pp.254 - 257 | - |
dc.relation.isPartOf | Blood Research | - |
dc.citation.title | Blood Research | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 254 | - |
dc.citation.endPage | 257 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001827933 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | antibiotic agent | - |
dc.subject.keywordPlus | immunoglobulin G | - |
dc.subject.keywordPlus | steroid | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | disseminated intravascular clotting | - |
dc.subject.keywordPlus | early diagnosis | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | hemophagocytic syndrome | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | medical record review | - |
dc.subject.keywordPlus | mucocutaneous lymph node syndrome | - |
dc.subject.keywordPlus | overall survival | - |
dc.subject.keywordPlus | preschool child | - |
dc.subject.keywordPlus | recurrent disease | - |
dc.subject.keywordPlus | recurrent fever | - |
dc.subject.keywordPlus | retrospective study | - |
dc.subject.keywordPlus | school child | - |
dc.subject.keywordPlus | treatment response | - |
dc.subject.keywordAuthor | Hemophagocytic lymphohistiocytosis | - |
dc.subject.keywordAuthor | Kawasaki disease | - |
dc.subject.keywordAuthor | Recurrent | - |
dc.identifier.url | https://synapse.koreamed.org/articles/1092096 | - |
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