Lobarstin Enhances Chemosensitivity in Human Glioblastoma T98G Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Sojin | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Lee, Hongki | - |
dc.contributor.author | Kim, Tae Ue | - |
dc.contributor.author | Kim, Il-Chan | - |
dc.contributor.author | Yim, Joung Han | - |
dc.contributor.author | Chung, Heekyoung | - |
dc.date.accessioned | 2022-07-16T07:07:38Z | - |
dc.date.available | 2022-07-16T07:07:38Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161314 | - |
dc.description.abstract | Background/Aim: Lobarstin is a metabolite occurring from the Antarctic lichen Stereocaulon alpnum. Human glioblastoma is highly resistant to chemotherapy with temozolomide. Lobarstin was examined for its effect on glioblastoma. Materials and Methods: Temozolomide-resistant T98G cells were subjected to toxicity test with temozolomide and/or lobarstin. DNA damage and recovery was assessed by the alkaline comet assay and expression of DNA repair genes was examined by RT-PCR and western blot analysis. Results: Lobarstin alone at 40 mu M was toxic against T98G, but had no effect in primary human fibroblasts. Co-treatment of lobarstin with temozolomide yielded enhanced toxicity. Temozolomide-alone or with lobarstin co-treatment gave similar extent of DNA damage. However, the recovery was reduced in co-treated cells. Expression of DNA repair genes, O-6-methylguanine-DNA methyltransferase, poly(ADPribose) polymerase I and ligase 3 were reduced in lobarstin-treated cells. Conclusion: Enhanced sensitivity to temozolomide by lobarstin co-treatment may be attributed to reduced DNA repair. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.title | Lobarstin Enhances Chemosensitivity in Human Glioblastoma T98G Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Heekyoung | - |
dc.identifier.scopusid | 2-s2.0-84891408808 | - |
dc.identifier.wosid | 000328801900028 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.33, no.12, pp.5445 - 5451 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 33 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5445 | - |
dc.citation.endPage | 5451 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | MALIGNANT GLIOMA | - |
dc.subject.keywordPlus | TEMOZOLOMIDE RESISTANCE | - |
dc.subject.keywordPlus | ALKYLATING-AGENTS | - |
dc.subject.keywordPlus | MGMT EXPRESSION | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | XENOGRAFTS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Lobarstin | - |
dc.subject.keywordAuthor | glioblastoma | - |
dc.subject.keywordAuthor | temozolomide | - |
dc.subject.keywordAuthor | chemosensitivity | - |
dc.subject.keywordAuthor | DNA repair | - |
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