Dicarbonyl/l-xylulose reductase (DCXR): The multifunctional pentosuria enzyme
- Authors
- Lee, Sun-Kyung; Son, Le Tho; Choi, Hee-Jung; Ahnn, Joohong
- Issue Date
- Nov-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dicarbonylk-xylulose dehydrogenase; dhs-21; Pentosuria; Longevity; Fertility
- Citation
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v.45, no.11, pp.2563 - 2567
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Volume
- 45
- Number
- 11
- Start Page
- 2563
- End Page
- 2567
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161537
- DOI
- 10.1016/j.biocel.2013.08.010
- ISSN
- 1357-2725
- Abstract
- Dicarbonyl/L-xylulose reductase (DCXR) is a highly conserved and phylogenetically widespread enzyme converting L-xylulose into xylitol. It also reduces highly reactive a-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. Enzymatic properties of DCXR from yeast, fungi and mammalian tissue extracts are extensively studied. Deficiency of the DCXR gene causes a human clinical condition called pentosuria and low DCXR activity is implicated in age-related diseases including cancers, diabetes, and human male infertility. While mice provide a model to study clinical condition of these diseases, it is necessary to adopt a physiologically tractable model in which genetic manipulations can be readily achieved to allow the fast genetic analysis of an enzyme with multiple biological roles. Caenorhabditis elegans has been successfully utilized as a model to study DCXR. Here, we discuss the biochemical properties and significance of DCXR activity in various human diseases, and the utility of C. elegans as a research platform to investigate the molecular and cellular mechanism of the DCXR biology.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161537)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.