Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model
DC Field | Value | Language |
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dc.contributor.author | Lee, Jangwook | - |
dc.contributor.author | Cha, Min-Ji | - |
dc.contributor.author | Lim, Kwang Suk | - |
dc.contributor.author | Kim, Jang-Kyung | - |
dc.contributor.author | Lee, Sang-Kyung | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.contributor.author | Hwang, Ki-Chul | - |
dc.contributor.author | Lee, Kuen Yong | - |
dc.date.accessioned | 2022-07-16T07:35:45Z | - |
dc.date.available | 2022-07-16T07:35:45Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161555 | - |
dc.description.abstract | Heat shock proteins, acting as molecular chaperones, protect heart muscle from ischemic injury and offer a potential approach to therapy. Here we describe preparation of an injectable form of heat shock protein 27, fused with a protein transduction domain (TAT-HSP27) and contained in a hybrid system of poly(D,L-lactic-co-glycolic acid) microsphere and alginate hydrogel. By varying the porous structure of the microspheres, the release of TAT-HSP27 from the hybrid system was sustained for two weeks in vitro. The hybrid system containing TAT-HSP27 was intramyocardially injected into a murine myocardial infarction model, and its therapeutic effect was evaluated in vivo. The sustained delivery of TAT-HSP27 substantially suppressed apoptosis in the infarcted site, and improved the ejection fraction, end-systolic volume and maximum pressure development in the heart. Local and sustained delivery of anti-apoptotic proteins such as HSP27 using a hybrid system may present a promising approach to the treatment of ischemic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.contributor.affiliatedAuthor | Lee, Kuen Yong | - |
dc.identifier.doi | 10.3109/1061186X.2013.829072 | - |
dc.identifier.scopusid | 2-s2.0-84885622831 | - |
dc.identifier.wosid | 000325712700004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DRUG TARGETING, v.21, no.9, pp.822 - 829 | - |
dc.relation.isPartOf | JOURNAL OF DRUG TARGETING | - |
dc.citation.title | JOURNAL OF DRUG TARGETING | - |
dc.citation.volume | 21 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 822 | - |
dc.citation.endPage | 829 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MEDIATED DELIVERY | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PTD | - |
dc.subject.keywordAuthor | Heat shock protein | - |
dc.subject.keywordAuthor | microsphere/hydrogel hybrid system | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/1061186X.2013.829072 | - |
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