Mutual effect of subcutaneously transplanted human adipose-derived stem cells and pancreatic islets within fibrin gel
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Jung, Min Jin | - |
dc.contributor.author | Shin, Jung-Youn | - |
dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Hwang, Yong Hwa | - |
dc.contributor.author | Kim, Min Jun | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.date.accessioned | 2022-07-16T07:59:27Z | - |
dc.date.available | 2022-07-16T07:59:27Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161807 | - |
dc.description.abstract | While subcutaneous tissue has been proposed as a potential site for pancreatic islet transplantation, concern remains that the microvasculature of subcutaneous tissue is too poor to support transplanted islets. In an effort to overcome this limitation, we evaluated whether fibrin gel with human adipose-derived stem cells (hADSCs) and rat pancreatic islets could cure diabetes mellitus when transplanted into the subcutaneous space of diabetic mice. Subcutaneously co-transplanted islets and hADSCs showed normalization of the diabetic recipient's blood glucose levels. The result was enhanced by co-treatment of fibroblast growth factor-2 (FGF2) in the fibrin gel. The hADSCs enhanced islet viability after transplantation by secreting various growth factors that can protect islets from hypoxic damage. Afterward, hADSCs could maintain islet viability by recruiting new microvasculature nearby the transplanted islets via overexpression of vascular endothelial growth factor (VEGF). The hADSCs did not directly differentiate into endothelial cells (no detection of biomarkers of human endothelial cells), but showed evidence of differentiation toward insulin-secreting cells (detection of human insulin). Mice receiving islet transplantation alone did not become normoglycemic. Collectively, co-transplantation of fibrin gel with islets and hADSCs will expand the indications for islet transplant therapy and the potential clinical application of cell-based therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Mutual effect of subcutaneously transplanted human adipose-derived stem cells and pancreatic islets within fibrin gel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1016/j.biomaterials.2013.06.018 | - |
dc.identifier.scopusid | 2-s2.0-84880511706 | - |
dc.identifier.wosid | 000322931900004 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.34, no.30, pp.7247 - 7256 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 7247 | - |
dc.citation.endPage | 7256 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IMPROVE POSTNATAL NEOVASCULARIZATION | - |
dc.subject.keywordPlus | DECREASED OXYGEN-TENSION | - |
dc.subject.keywordPlus | GROWTH-FACTOR 2 | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | EDMONTON PROTOCOL | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | IMPLANTATION SITE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordAuthor | Adipose-derived stem cells | - |
dc.subject.keywordAuthor | Pancreatic islets | - |
dc.subject.keywordAuthor | Transplantation | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961213007047?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.