Heterotrimeric G-Protein, G(alpha 16), Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Avasarala, Sreedevi | - |
dc.contributor.author | Bikkavilli, Rama Kamesh | - |
dc.contributor.author | Van Scoyk, Michelle | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Lapite, Ajibike | - |
dc.contributor.author | Hostetter, Logan | - |
dc.contributor.author | Byers, Joshua T. | - |
dc.contributor.author | Heasley, Lynn E. | - |
dc.contributor.author | Sohn, Jang Won | - |
dc.contributor.author | Winn, Robert A. | - |
dc.date.accessioned | 2022-07-16T08:14:07Z | - |
dc.date.available | 2022-07-16T08:14:07Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/161869 | - |
dc.description.abstract | G-protein-coupled receptors (GPCR) are the largest family of cell surface molecules that play important role/s in a number of biological and pathological processes including cancers. Earlier studies have highlighted the importance of Wnt7a signaling via its cognate receptor Frizzled9, a GPCR, in inhibition of cell proliferation, anchorage-independent growth, and reversal of transformed phenotype in non small cell lung cancer primarily through activation of the tumor suppressor, PPAR gamma. However, the G-protein effectors that couple to this important tumor suppressor pathway have not been identified, and are of potential therapeutic interest. In this study, by using two independent Wnt7a/Frizzled9-specific read-outs, we identify G(alpha 16) as a novel downstream effector of Wnt7a/Frizzled9 signaling. Interestingly, G(alpha 16) expression is severely down-regulated, both at the messenger RNA levels and protein levels, in many non small cell lung cancer cell lines. Additionally, through gene-specific knock-downs and expression of GTPase-deficient forms (Q212L) of G(alpha 16), we also establish G(alpha 16) as a novel regulator of non small cell lung cancer cell proliferation and anchorage-independent cell growth. Taken together, our data not only establish the importance of G(alpha 16) as a critical downstream effector of the non-canonical Wnt signaling pathway but also as a potential therapeutic target for the treatment of non small cell lung cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Heterotrimeric G-Protein, G(alpha 16), Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Jang Won | - |
dc.identifier.doi | 10.1371/journal.pone.0076895 | - |
dc.identifier.scopusid | 2-s2.0-84885783948 | - |
dc.identifier.wosid | 000326029300062 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.10, pp.1 - 11 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ACTIVATED-RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITIONS | - |
dc.subject.keywordPlus | COUPLED RECEPTORS | - |
dc.subject.keywordPlus | TERATOCARCINOMA CELLS | - |
dc.subject.keywordPlus | RAT FRIZZLED-1 | - |
dc.subject.keywordPlus | TCF PATHWAY | - |
dc.subject.keywordPlus | CYCLIC-GMP | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076895 | - |
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