Virtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26
DC Field | Value | Language |
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dc.contributor.author | Park, Hwangseo | - |
dc.contributor.author | Kyung, Ayoung | - |
dc.contributor.author | Lee, Hyun-Ju | - |
dc.contributor.author | Kang, Sunghyun | - |
dc.contributor.author | Yoon, Tae-Sung | - |
dc.contributor.author | Ryu, Seong Eon | - |
dc.contributor.author | Jeong, Dae Gwin | - |
dc.date.accessioned | 2022-07-16T08:46:41Z | - |
dc.date.available | 2022-07-16T08:46:41Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1054-2523 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162245 | - |
dc.description.abstract | Dual-specificity phosphatase 26 (DUSP26) has recently proved to be a promising therapeutical target for the treatment of human cancers. Here, we report the first example for a successful application of the structure-based virtual screening approach to identify nine novel inhibitors of DUSP26. These inhibitors are also screened for having desirable physicochemical properties as drug candidates and reveal a high potency with IC50 values ranging from 8 to 42 mu M. Therefore, they deserve consideration for further development by structure-activity relationship (SAR) studies to optimize the anticancer activities. Structural features relevant to the stabilization of the newly identified inhibitors in the active site of DUSP26 are addressed in detail. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BIRKHAUSER | - |
dc.title | Virtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Seong Eon | - |
dc.identifier.doi | 10.1007/s00044-012-0405-3 | - |
dc.identifier.scopusid | 2-s2.0-84879499110 | - |
dc.identifier.wosid | 000320673200036 | - |
dc.identifier.bibliographicCitation | MEDICINAL CHEMISTRY RESEARCH, v.22, no.8, pp.3905 - 3910 | - |
dc.relation.isPartOf | MEDICINAL CHEMISTRY RESEARCH | - |
dc.citation.title | MEDICINAL CHEMISTRY RESEARCH | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3905 | - |
dc.citation.endPage | 3910 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | GENETIC ALGORITHM | - |
dc.subject.keywordPlus | SOLVATION | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | DOCKING | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DUSP26 | - |
dc.subject.keywordAuthor | Virtual screening | - |
dc.subject.keywordAuthor | DUSP26 | - |
dc.subject.keywordAuthor | Inhibitor | - |
dc.subject.keywordAuthor | Docking | - |
dc.subject.keywordAuthor | Anticancer agents | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00044-012-0405-3 | - |
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