Superoxide Anion Production by Human Neutrophils Activated by Trichomonas vaginalis
DC Field | Value | Language |
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dc.contributor.author | Song, Hyun-Ouk | - |
dc.contributor.author | Ryu, Jae-Sook | - |
dc.date.accessioned | 2022-07-16T08:48:31Z | - |
dc.date.available | 2022-07-16T08:48:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0023-4001 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162263 | - |
dc.description.abstract | Neutrophils are the predominant inflammatory cells found in vaginal discharges of patients infected with Trichomonas vaginalis. In this study, we examined superoxide anion (O-2(center dot-)) production by neutrophils activated by T vaginalis. Human neutrophils produced superoxide anions when stimulated with either a lysate of T vaginalis, its membrane component (MC), or excretory-secretory product (ESP). To assess the role of trichomonad protease in production of superoxide anions by neutrophils, T vaginalis lysate, ESP, and MC were each pretreated with a protease inhibitor cocktail before incubation with neutrophils. Superoxide anion production was significantly decreased by this treatment. Trichomonad growth was inhibited by preincubation with supernatants of neutrophils incubated for 3 hr with T vaginalis lysate. Furthermore, myeloperoxidase (MPO) production by neutrophils was stimulated by live trichomonads. These results indicate that the production of superoxide anions and MPO by neutrophils stimulated with T vaginalis may be a part of defense mechanisms of neutrophils in trichomoniasis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI | - |
dc.title | Superoxide Anion Production by Human Neutrophils Activated by Trichomonas vaginalis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-Sook | - |
dc.identifier.doi | 10.3347/kjp.2013.51.4.479 | - |
dc.identifier.scopusid | 2-s2.0-84884160213 | - |
dc.identifier.wosid | 000324602900014 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PARASITOLOGY, v.51, no.4, pp.479 - 484 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PARASITOLOGY | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 484 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002164105 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | HYPOCHLOROUS ACID | - |
dc.subject.keywordPlus | MYELOPEROXIDASE DEFICIENCY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | INTERLEUKIN-8 | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | Trichomonas vaginalis | - |
dc.subject.keywordAuthor | neutrophil | - |
dc.subject.keywordAuthor | superoxide anion | - |
dc.subject.keywordAuthor | myeloperoxidase | - |
dc.subject.keywordAuthor | growth inhibition | - |
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