Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta(2) expression via DNA methylation
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyehyeon | - |
dc.contributor.author | Woo, Young-Ju | - |
dc.contributor.author | Kim, Soo Shin | - |
dc.contributor.author | Kim, Sung-Hyun | - |
dc.contributor.author | Park, Bum-Joon | - |
dc.contributor.author | Choi, Dong ho | - |
dc.contributor.author | Jang, Kyung Lib | - |
dc.date.accessioned | 2022-07-16T09:04:05Z | - |
dc.date.available | 2022-07-16T09:04:05Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162327 | - |
dc.description.abstract | Aberrant promoter methylation of tumor suppressor genes including retinoic acid receptor-beta(2) (RAR-beta(2)) is frequently detected in hepatitis C virus (HCV)-associated hepatocellular carcinoma; however, the mechanism and its significance are relatively unknown. Here, we showed that HCV Core induced promoter hypermethylation of RAR-beta(2) to inhibit its expression via up-regulation of DNA methyltransferases 1 and 3b. Under the condition, all-trans retinoic acid (ATRA) failed to activate p16 expression and thus could not inactivate the Rb-E2F pathway. Accordingly, Core-expressing cells exhibited resistance to ATRA-induced growth inhibition. Taken together, HCV Core antagonizes ATRA, a natural anti-cancer compound, to stimulate cell growth via epigenetic down-regulation of RAR-beta(2). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta(2) expression via DNA methylation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Dong ho | - |
dc.identifier.doi | 10.1016/j.canlet.2013.02.057 | - |
dc.identifier.scopusid | 2-s2.0-84878238259 | - |
dc.identifier.wosid | 000320682500014 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.335, no.2, pp.372 - 379 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 335 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 372 | - |
dc.citation.endPage | 379 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENES | - |
dc.subject.keywordPlus | E-CADHERIN EXPRESSION | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | PROMOTER HYPOMETHYLATION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | X PROTEIN | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | All-trans retinoic acid | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.subject.keywordAuthor | HCV Core | - |
dc.subject.keywordAuthor | Retinoic acid receptor-beta(2) | - |
dc.subject.keywordAuthor | p16 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304383513002206?via%3Dihub | - |
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