Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyuri | - |
dc.contributor.author | Ryu, Ji Hyun | - |
dc.contributor.author | Lee, Dong Yun | - |
dc.contributor.author | Lee, Haeshin | - |
dc.date.accessioned | 2022-07-16T09:08:33Z | - |
dc.date.available | 2022-07-16T09:08:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162370 | - |
dc.description.abstract | This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxy-hydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL(-1) at pH 7.0. The degree of catechol conjugation was found critical in determining the solubility. The chitosan-catechol conjugates are not only water-soluble but are adhesive, due to the intrinsic adhesive properties of catechol. Also, the water-soluble chitosan derivative allows one to directly form chitosan hydrogel in neutral buffer solutions. The utility of both the water solubility and the adhesive property of the chitosan-catechol was demonstrated by the effective layer-by-layer assembly on substrates. The water-soluble chitosan-catechol is expected to be useful in many areas of surface functionalization, drug delivery, tissue engineering, and tissue adhesives. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Yun | - |
dc.identifier.doi | 10.1039/c3bm00004d | - |
dc.identifier.scopusid | 2-s2.0-84883230992 | - |
dc.identifier.wosid | 000330136100011 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS SCIENCE, v.1, no.7, pp.783 - 790 | - |
dc.relation.isPartOf | BIOMATERIALS SCIENCE | - |
dc.citation.title | BIOMATERIALS SCIENCE | - |
dc.citation.volume | 1 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 783 | - |
dc.citation.endPage | 790 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | IMPROVES | - |
dc.subject.keywordPlus | DOPA | - |
dc.subject.keywordPlus | PH | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2013/BM/c3bm00004d | - |
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