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Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

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dc.contributor.authorChun, Kwangwoo-
dc.contributor.authorPark, Ji-Seon-
dc.contributor.authorLee, Han-Chang-
dc.contributor.authorKim, Young-Ha-
dc.contributor.authorYe, In-Hea-
dc.contributor.authorKim, Kang-Jeon-
dc.contributor.authorKu, Il-Whea-
dc.contributor.authorNoh, Min-Young-
dc.contributor.authorCho, Goang-Won-
dc.contributor.authorKim, Heejaung-
dc.contributor.authorKim, Seung Hyun-
dc.contributor.authorKim, Jeongmin-
dc.date.accessioned2022-07-16T09:12:53Z-
dc.date.available2022-07-16T09:12:53Z-
dc.date.issued2013-07-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162407-
dc.description.abstractNew potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 mu M). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPergamon Press Ltd.-
dc.titleSynthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2013.03.119-
dc.identifier.scopusid2-s2.0-84878847216-
dc.identifier.wosid000320702900058-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.13, pp 3983 - 3987-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number13-
dc.citation.startPage3983-
dc.citation.endPage3987-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusACTIVE-SITE-
dc.subject.keywordPlusINDIRUBINS-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusDOCKING-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusROLES-
dc.subject.keywordAuthorGlycogen synthase kinase-3-
dc.subject.keywordAuthorGSK-3 inhibitor-
dc.subject.keywordAuthor8-Amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0960894X13004472?via%3Dihub-
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