Effects of Beraprost Sodium on subjective symptoms in diabetic patients with peripheral arterial disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, H.S. | - |
dc.contributor.author | Choi, W.J. | - |
dc.contributor.author | Sung, I.H. | - |
dc.contributor.author | Lee, H.S. | - |
dc.contributor.author | Chung, H.J. | - |
dc.contributor.author | Lee, J.W. | - |
dc.date.accessioned | 2022-07-16T09:34:59Z | - |
dc.date.available | 2022-07-16T09:34:59Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 2005-291x | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162598 | - |
dc.description.abstract | Background: This study evaluated the effects of Beraprost sodium (Berasil) on subjective leg symptoms in patients with peripheral arterial disease caused by diabetes mellitus. Methods: Ninety-four diabetic patients with peripheral arterial disease were treated with Beraprost in a fixed-dose, prospective, multicenter, cohort study. Beraprost (40 µg) was administered orally 3 times daily (120 µg/day) for 12 weeks. We developed a new disease-specific symptom questionnaire, which evaluated the effect of peripheral arterial disease on leg discomfort in daily life and assessed therapeutic responses to treatment. Patients were asked for their subjective assessment of symptoms on a written questionnaire before treatment and after 12 weeks of therapy. Results: There was significant improvement in all estimated subjective symptoms (burning, coldness, edema, exertional pain, stabbing, and paresthesias) in the lower extremities at 12 weeks (p < 0.001). There were 18 patients with neuropathy in whom significant improvement was noted for 6 subjective symptoms at 12 weeks (p < 0.05). Adverse events considered to be drug-related were observed in 4 patients (4.3%), all of which were mild and resolved with discontinuation of the medication. Conclusions: Beraprost is effective as a treatment for improving various subjective symptoms in the lower extremities, such as burning, coldness, edema, exertional pain, stabbing, and paresthesias, in diabetic patients with peripheral arterial disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Orthopaedic Association | - |
dc.title | Effects of Beraprost Sodium on subjective symptoms in diabetic patients with peripheral arterial disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, I.H. | - |
dc.identifier.doi | 10.4055/cios.2013.5.2.145 | - |
dc.identifier.scopusid | 2-s2.0-84878156565 | - |
dc.identifier.bibliographicCitation | Clinics in Orthopedic Surgery, v.5, no.2, pp.145 - 151 | - |
dc.relation.isPartOf | Clinics in Orthopedic Surgery | - |
dc.citation.title | Clinics in Orthopedic Surgery | - |
dc.citation.volume | 5 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 151 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001901189 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordPlus | beraprost | - |
dc.subject.keywordPlus | berasil | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | burning sensation | - |
dc.subject.keywordPlus | cohort analysis | - |
dc.subject.keywordPlus | cold | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diabetes mellitus | - |
dc.subject.keywordPlus | diabetic patient | - |
dc.subject.keywordPlus | drug activity | - |
dc.subject.keywordPlus | drug efficacy | - |
dc.subject.keywordPlus | drug induced headache | - |
dc.subject.keywordPlus | drug withdrawal | - |
dc.subject.keywordPlus | dyspepsia | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | functional assessment | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | insomnia | - |
dc.subject.keywordPlus | leg edema | - |
dc.subject.keywordPlus | leg pain | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | multicenter study | - |
dc.subject.keywordPlus | neuropathy | - |
dc.subject.keywordPlus | paresthesia | - |
dc.subject.keywordPlus | peripheral occlusive artery disease | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | questionnaire | - |
dc.subject.keywordPlus | treatment response | - |
dc.subject.keywordAuthor | Beraprost Sodium | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Intermittent claudication | - |
dc.subject.keywordAuthor | Peripheral arterial disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.