High Cholesterol Diet Induces IL-1 beta Expression in Adult but Not Larval Zebrafish
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Yina | - |
dc.contributor.author | Yoon, Jihye | - |
dc.contributor.author | Jang, Man-Young | - |
dc.contributor.author | Na, Yirang | - |
dc.contributor.author | Ko, Youngho | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Seok, Seung Hyeok | - |
dc.date.accessioned | 2022-07-16T09:44:08Z | - |
dc.date.available | 2022-07-16T09:44:08Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162693 | - |
dc.description.abstract | Recently, it has been demonstrated that high cholesterol diet induced hypercholesterolemia and vascular lipid oxidation and accumulation in zebrafish larvae, suggesting that zebrafish is a new promising atherosclerosis model in addition to mouse models. However, up to date, there was no report regarding inflammatory cytokine expression during the lipid accumulation in zebrafish larva and adult fish. In this study, we first demonstrated the expression levels of IL-1 beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae, and found that although HCD induced vascular lipid accumulation, the cytokine expressions in the larvae were not changed by HCD. Furthermore, there was no significant difference in leukocyte accumulation in vessels between control and HCD fed group. But prolonged HCD induced IL-1 beta expression in spleen and liver compared to those of control zebrafish, and produced very early stage of fatty streak lesion in dorsal aorta of 19 week HCD-fed zebrafish. These results indicate that HCD induced hypercholesterolemia and atherosclerotic changes in zebrafish are very early stage, and suggest the necessity of the generation of mutant zebrafish having a disruption in a lipid metabolism-related gene leading to severe hypercholesterolemia and advanced atherosclerosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | High Cholesterol Diet Induces IL-1 beta Expression in Adult but Not Larval Zebrafish | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jae-Hoon | - |
dc.identifier.doi | 10.1371/journal.pone.0066970 | - |
dc.identifier.scopusid | 2-s2.0-84879375358 | - |
dc.identifier.wosid | 000321223000054 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.6, pp.1 - 8 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | TARGETED GENE DISRUPTION | - |
dc.subject.keywordPlus | ZINC-FINGER NUCLEASES | - |
dc.subject.keywordPlus | MOUSE MODELS | - |
dc.subject.keywordPlus | HYPERCHOLESTEROLEMIC ZEBRAFISH | - |
dc.subject.keywordPlus | LIPID-ACCUMULATION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | TALENS | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066970 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.