House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway
DC Field | Value | Language |
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dc.contributor.author | Ro, Eun Ji | - |
dc.contributor.author | Cha, Pu-Hyeon | - |
dc.contributor.author | Kim, Hyun-Yi | - |
dc.contributor.author | Cho, Yong-Hee | - |
dc.contributor.author | Park, Jung-Won | - |
dc.contributor.author | Han, Joong-Soo | - |
dc.contributor.author | Choi, Kang-Yell | - |
dc.date.accessioned | 2022-07-16T10:09:22Z | - |
dc.date.available | 2022-07-16T10:09:22Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0257-277X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162871 | - |
dc.description.abstract | House dust mites (HDMs) are a common cause of allergic asthma. The group 2 allergen from Dermatophagoides farinae, Der f 2, is one of the major HDM allergens. Elevated Der f 2 immunoglobulin E (IgE) levels are observed in most of the allergic patients. Interleukin-13 (IL-13), a gene associated with asthma pathology, was induced by Der f 2 in BEAS-2B human airway epithelial cells; however, the signaling pathways associated with Der f 2 are not fully understood. In this study, we identified a role of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a well-known potential target for anti-asthma drugs, in the IL-13 induction by Der f 2. First, Der f 2 activated the PI3K/Akt pathway, which subsequently activated the nuclear factor-kappa B (NF-kappa B) pathway and induced IL-13 expression in BEAS-2B cells. Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-kappa B and the expression of IL-13. Furthermore, Der f 2-induced activation of the PI3K/Akt and NF-kappa B pathways, expression of IL-13, and the blockade of these effects with a PI3K inhibitor were confirmed in the lungs of mice that were intranasally exposed to Der f 2. Taken together, these results indicate that the PI3K/Akt pathway regulates Der f 2-induced IL-13 expression via activation of the NF-kappa B pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HUMANA PRESS INC | - |
dc.title | House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Joong-Soo | - |
dc.identifier.doi | 10.1007/s12026-013-8392-0 | - |
dc.identifier.scopusid | 2-s2.0-84876412827 | - |
dc.identifier.wosid | 000317849100018 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGIC RESEARCH, v.56, no.1, pp.181 - 188 | - |
dc.relation.isPartOf | IMMUNOLOGIC RESEARCH | - |
dc.citation.title | IMMUNOLOGIC RESEARCH | - |
dc.citation.volume | 56 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 188 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | BRONCHIAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | 3-KINASE | - |
dc.subject.keywordAuthor | Der f 2 | - |
dc.subject.keywordAuthor | IL-13 | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | NF-kappa beta | - |
dc.subject.keywordAuthor | Airway epithelial cells | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12026-013-8392-0 | - |
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