Impact of Diabetes on Treatment Outcomes and Long-Term Survival in Multidrug-Resistant Tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Kang, Young Ae | - |
dc.contributor.author | Kim, Song Yee | - |
dc.contributor.author | Jo, Kyung-Wook | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Park, Seung-Kyu | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Lee, Ki Man | - |
dc.contributor.author | Lee, Sung Soon | - |
dc.contributor.author | Park, Jae Seuk | - |
dc.contributor.author | Koh, Won-Jung | - |
dc.contributor.author | Kim, Dae Yun | - |
dc.contributor.author | Shim, Tae Sun | - |
dc.date.accessioned | 2022-07-16T10:16:23Z | - |
dc.date.available | 2022-07-16T10:16:23Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/162934 | - |
dc.description.abstract | Background: Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms of tuberculosis (MDR-TB). Objectives: We analyzed outcomes in a large cohort to assess the impact of DM on treatment outcomes of patients with MDR-TB. Methods: MDR-TB patients newly diagnosed or retreated between 2000 and 2002 and followed for 8-11 years were retrospectively analyzed with respect to the effect of DM as a comorbidity on their treatment outcome and long-term survival. Results: Of 1,407 patients with MDR-TB, 239 (17.0%) had coexisting DM. The mean age and body mass index were higher in MDR-TB patients with DM [MDRTBDM(+)] than in those without DM [MDR-TBDM(-)]. Patients with MDR-TB and a comorbidity of DM had a significantly lower treatment success rate than those without a history of DM (36.0 vs. 47.2%, p = 0.002). In addition, DM was the negative predictor for MDR-TB treatment success in multivariate analyses [odds ratio 0.51, 95% confidence interval (CI) 0.26-0.99]. Mean survival times were also lower in MDR-TBDM(+) than in MDR-TBDM(-) patients (102 vs. 114 months, p = 0.001), with DM as a significant predictor of poor long-term survival in multivariate analyses (hazard ratio 1.59, 95% CI 1.01-2.50). Conclusions: Among MDR-TB patients, DM was a relatively common comorbidity. In patients undergoing treatment for MDR-TB and followed for 8-11 years, it was found to be independently associated with an increased risk of both treatment failure and death. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Impact of Diabetes on Treatment Outcomes and Long-Term Survival in Multidrug-Resistant Tuberculosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hyung | - |
dc.identifier.doi | 10.1159/000348374 | - |
dc.identifier.scopusid | 2-s2.0-84893698526 | - |
dc.identifier.wosid | 000329924300004 | - |
dc.identifier.bibliographicCitation | RESPIRATION, v.86, no.6, pp.472 - 478 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.citation.title | RESPIRATION | - |
dc.citation.volume | 86 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 478 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TB | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Multidrug-resistant tuberculosis | - |
dc.subject.keywordAuthor | Treatment | - |
dc.subject.keywordAuthor | Outcome | - |
dc.subject.keywordAuthor | Survival | - |
dc.identifier.url | https://www.karger.com/Article/FullText/348374 | - |
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