A case of microscopic polyangiitis associated with aortic valve insufficiency
DC Field | Value | Language |
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dc.contributor.author | Kim, Bae Keun | - |
dc.contributor.author | Park, So-Yeon | - |
dc.contributor.author | Choi, Chan-Bum | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Jun, Jae-Bum | - |
dc.contributor.author | Jang, Se Min | - |
dc.contributor.author | Park, Moon Hyang | - |
dc.contributor.author | Uhm, Wan-Sik | - |
dc.date.accessioned | 2022-07-16T10:25:06Z | - |
dc.date.available | 2022-07-16T10:25:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163055 | - |
dc.description.abstract | Microscopic polyangiitis (MPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by inflammation of small-sized vessels. Although there have been some reports of ANCA-associated vasculitis presenting as aortitis syndrome, MPA rarely involves large-sized vessels such as the aorta. We report an unusual case of MPA combined with severe acute aortic valve insufficiency in a 56-year-old man. He initially presented with prolonged fever, skin rash, and rapidly progressive glomerulonephritis. P-ANCA and anti-myeloperoxidase (MPO) antibodies were positive, but the c-ANCA and anti-proteinase-3 antibodies were negative. Skin biopsy of the lower leg showed necrotizing arteritis. Kidney biopsy was also performed, which revealed diffuse necrotizing and crescentic glomerulonephritis (GN) consistent with pauci-immune ANCA-associated GN. Serial echocardiographic evaluations revealed aortic valve changes and worsening acute aortic valve insufficiency over a two-month period. Despite intensive treatment, our patient developed sudden cardiac arrest and died. Our patient demonstrated typical clinical features and histopathologic findings for systemic vasculitis and had a positive anti-MPO antibody, all of which were consistent with the diagnosis of MPA. Thus, MPA may have been the cause of acute aortic valve insufficiency in this case. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | A case of microscopic polyangiitis associated with aortic valve insufficiency | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Chan-Bum | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Jun, Jae-Bum | - |
dc.identifier.doi | 10.1007/s00296-010-1639-3 | - |
dc.identifier.scopusid | 2-s2.0-84886617497 | - |
dc.identifier.wosid | 000316971800036 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.33, no.4, pp.1055 - 1058 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1055 | - |
dc.citation.endPage | 1058 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | ANTINEUTROPHIL CYTOPLASMIC ANTIBODY | - |
dc.subject.keywordPlus | VASCULITIDES | - |
dc.subject.keywordPlus | VESSEL | - |
dc.subject.keywordAuthor | Microscopic polyangiitis | - |
dc.subject.keywordAuthor | Aortic valve insufficiency | - |
dc.subject.keywordAuthor | Anti-neutrophil cytoplasmic antibody | - |
dc.subject.keywordAuthor | Vasculitis | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00296-010-1639-3 | - |
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