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A case of microscopic polyangiitis associated with aortic valve insufficiency

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dc.contributor.authorKim, Bae Keun-
dc.contributor.authorPark, So-Yeon-
dc.contributor.authorChoi, Chan-Bum-
dc.contributor.authorKim, Tae-Hwan-
dc.contributor.authorJun, Jae-Bum-
dc.contributor.authorJang, Se Min-
dc.contributor.authorPark, Moon Hyang-
dc.contributor.authorUhm, Wan-Sik-
dc.date.accessioned2022-07-16T10:25:06Z-
dc.date.available2022-07-16T10:25:06Z-
dc.date.created2021-05-12-
dc.date.issued2013-04-
dc.identifier.issn0172-8172-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163055-
dc.description.abstractMicroscopic polyangiitis (MPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by inflammation of small-sized vessels. Although there have been some reports of ANCA-associated vasculitis presenting as aortitis syndrome, MPA rarely involves large-sized vessels such as the aorta. We report an unusual case of MPA combined with severe acute aortic valve insufficiency in a 56-year-old man. He initially presented with prolonged fever, skin rash, and rapidly progressive glomerulonephritis. P-ANCA and anti-myeloperoxidase (MPO) antibodies were positive, but the c-ANCA and anti-proteinase-3 antibodies were negative. Skin biopsy of the lower leg showed necrotizing arteritis. Kidney biopsy was also performed, which revealed diffuse necrotizing and crescentic glomerulonephritis (GN) consistent with pauci-immune ANCA-associated GN. Serial echocardiographic evaluations revealed aortic valve changes and worsening acute aortic valve insufficiency over a two-month period. Despite intensive treatment, our patient developed sudden cardiac arrest and died. Our patient demonstrated typical clinical features and histopathologic findings for systemic vasculitis and had a positive anti-MPO antibody, all of which were consistent with the diagnosis of MPA. Thus, MPA may have been the cause of acute aortic valve insufficiency in this case.-
dc.language영어-
dc.language.isoen-
dc.publisherSPRINGER HEIDELBERG-
dc.titleA case of microscopic polyangiitis associated with aortic valve insufficiency-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoi, Chan-Bum-
dc.contributor.affiliatedAuthorKim, Tae-Hwan-
dc.contributor.affiliatedAuthorJun, Jae-Bum-
dc.identifier.doi10.1007/s00296-010-1639-3-
dc.identifier.scopusid2-s2.0-84886617497-
dc.identifier.wosid000316971800036-
dc.identifier.bibliographicCitationRHEUMATOLOGY INTERNATIONAL, v.33, no.4, pp.1055 - 1058-
dc.relation.isPartOfRHEUMATOLOGY INTERNATIONAL-
dc.citation.titleRHEUMATOLOGY INTERNATIONAL-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage1055-
dc.citation.endPage1058-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaRheumatology-
dc.relation.journalWebOfScienceCategoryRheumatology-
dc.subject.keywordPlusANTINEUTROPHIL CYTOPLASMIC ANTIBODY-
dc.subject.keywordPlusVASCULITIDES-
dc.subject.keywordPlusVESSEL-
dc.subject.keywordAuthorMicroscopic polyangiitis-
dc.subject.keywordAuthorAortic valve insufficiency-
dc.subject.keywordAuthorAnti-neutrophil cytoplasmic antibody-
dc.subject.keywordAuthorVasculitis-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00296-010-1639-3-
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