Bacteroides fragilis enterotoxin upregulates lipocalin-2 expression in intestinal epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Yoo, Do Young | - |
dc.contributor.author | Ko, Su Hyuk | - |
dc.contributor.author | Jung, Jireh | - |
dc.contributor.author | Kim, Young-Jeon | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.date.accessioned | 2022-07-16T10:25:24Z | - |
dc.date.available | 2022-07-16T10:25:24Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0023-6837 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163057 | - |
dc.description.abstract | Enterotoxigenic Bacteroides fragilis (ETBF) produces an similar to 20 kDa B. fragilis enterotoxin (BFT), which plays an essential role in mucosal inflammation. Lipocalin (Lcn)-2, a siderophore-binding antimicrobial protein, is critical for control of bacterial infection; however, expression of Lcn-2 in BFT-exposed intestinal epithelial cells has not been elucidated. In the present study, stimulation of human intestinal epithelial cells with BFT resulted in the upregulation of Lcn-2 expression that was a relatively late response of intestinal epithelial cells compared with human beta-defensin (hBD)-2 expression. The upregulation of Lcn-2 was dependent on AP-1 but not on NF-kappa B signaling. Lcn-2 induction via AP-1 was regulated by mitogen-activated protein kinases (MAPKs) including ERK and p38. Lcn-2 was secreted from the apical and basolateral surfaces in BFT-treated cells. These results suggest that a signaling pathway involving MAPKs and AP-1 is required for Lcn-2 induction in intestinal epithelial cells exposed to BFT, after which the secreted Lcn-2 may facilitate antimicrobial activity within ETBF-infected mucosa. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Bacteroides fragilis enterotoxin upregulates lipocalin-2 expression in intestinal epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.1038/labinvest.2013.1 | - |
dc.identifier.scopusid | 2-s2.0-84875749804 | - |
dc.identifier.wosid | 000316804500002 | - |
dc.identifier.bibliographicCitation | LABORATORY INVESTIGATION, v.93, no.4, pp.384 - 396 | - |
dc.relation.isPartOf | LABORATORY INVESTIGATION | - |
dc.citation.title | LABORATORY INVESTIGATION | - |
dc.citation.volume | 93 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 384 | - |
dc.citation.endPage | 396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CLOSTRIDIUM-DIFFICILE TOXIN | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | ACTIVATOR PROTEIN-1 | - |
dc.subject.keywordPlus | HUMAN BETA-DEFENSIN-2 | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | Bacteroides fragilis enterotoxin | - |
dc.subject.keywordAuthor | intestinal epithelial cells | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase | - |
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