Degradome sequencing reveals an endogenous microRNA target in C. elegans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, June Hyun | - |
dc.contributor.author | Ahn, Soungyub | - |
dc.contributor.author | Kim, Soyoung | - |
dc.contributor.author | Lee, Junho | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.contributor.author | Shin, Chanseok | - |
dc.date.accessioned | 2022-07-16T10:30:47Z | - |
dc.date.available | 2022-07-16T10:30:47Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163114 | - |
dc.description.abstract | Caenorhabditis elegans microRNAs (miRNAs) bind to partially complementary sequences in the 3' untranslated region of target mRNAs, resulting in translational repression through mRNA destabilization. High-throughput sequencing of RNA cleavage fragments was performed to directly detect miRNA-directed cleavage targets in adult stage C. elegans. From this analysis, we found that miR-249 directed the cleavage of the ZK637.6 transcript with extensive and evolutionarily conserved complementarity in nematode. In addition, expression of the ZK637.6 transcript was strongly dependent on the expression of miR-249. These findings may lead to a better understanding of miRNA-mediated gene regulation in nematodes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Degradome sequencing reveals an endogenous microRNA target in C. elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Jin-Wu | - |
dc.identifier.doi | 10.1016/j.febslet.2013.02.029 | - |
dc.identifier.scopusid | 2-s2.0-84875270954 | - |
dc.identifier.wosid | 000316799600023 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.587, no.7, pp.964 - 969 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 587 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 964 | - |
dc.citation.endPage | 969 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | MIRNA TARGETS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | SITES | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Degradome sequencing | - |
dc.subject.keywordAuthor | MicroRNA-directed cleavage | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.identifier.url | https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2013.02.029 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.