Antioxidant effect of captopril and enalapril on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta
DC Field | Value | Language |
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dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Kim, Y.H. | - |
dc.contributor.author | Chung, W.-S. | - |
dc.contributor.author | Suh, J.K. | - |
dc.contributor.author | Kim, S.J. | - |
dc.date.accessioned | 2022-07-16T12:02:42Z | - |
dc.date.available | 2022-07-16T12:02:42Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2233-601X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/163809 | - |
dc.description.abstract | Background: Reactive oxygen species (ROS) are known to be related to cardiovascular diseases. Many studies have demonstrated that angiotensin-converting enzyme inhibitors have beneficial effects against ROS. We investigated the antioxidant effect of captopril and enalapril in nitric oxide mediated vascular endothelium-dependent relaxations. Materials and Methods: Isolated rabbit abdominal aorta ring segments were exposed to ROS by electrolysis of the organ bath medium (Krebs-Henseleit solution) after pretreatment with various concentrations (range, 10⁻⁵ to 3*10⁻⁴ M) of captopril and enalapril. Before and after electrolysis, the endothelial function was measured by preconstricting the vessels with norepinephrine (10⁻⁶ M) followed by the cumulative addition of acetylcholine (range, 3*10⁻⁸ to 10⁻⁶ M). The relevance of the superoxide anion and hydrogen peroxide scavenging effect of captopril and enalapril was investigated using additional pretreatments of diethyldithiocarbamate (DETCA, 0.5 mM), an inhibitor of Cu/Zn superoxide dismutase, and 3-amino-1,2,4-triazole (3AT, 50 mM), an inhibitor of catalase. Results: Both captopril and enalapril preserved vascular endothelium-dependent relaxation after exposure to ROS in a dose-dependent manner (p<0.0001). Pretreatment with DETCA attenuated the antioxidant effect of captopril and enalapril (p<0.0001), but pretreatment with 3AT did not have an effect. Conclusion: Both captopril and enalapril protect endothelium against ROS in a dose-dependent fashion in isolated rabbit abdominal aortas. This protective effect is related to superoxide anion scavenging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society for Thoracic and Cardiovascular Surgery | - |
dc.title | Antioxidant effect of captopril and enalapril on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, H. | - |
dc.contributor.affiliatedAuthor | Chung, W.-S. | - |
dc.identifier.doi | 10.5090/kjtcs.2013.46.1.14 | - |
dc.identifier.scopusid | 2-s2.0-84874989178 | - |
dc.identifier.bibliographicCitation | Korean Journal of Thoracic and Cardiovascular Surgery, v.46, no.1, pp.14 - 21 | - |
dc.relation.isPartOf | Korean Journal of Thoracic and Cardiovascular Surgery | - |
dc.citation.title | Korean Journal of Thoracic and Cardiovascular Surgery | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14 | - |
dc.citation.endPage | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001740965 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Angiotensin-converting enzyme inhibitors | - |
dc.subject.keywordAuthor | Captopril | - |
dc.subject.keywordAuthor | Enalapril | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Vasodilation | - |
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