Impact of genetic variants on major bleeding after percutaneous coronary intervention based on a prospective multicenter registryopen access
- Authors
- Cha, Jung-Joon; Joo, Hyung Joon; Park, Jae Hyoung; Hong, Soon Jun; Ahn, Tae Hoon; Kim, Byeong-Keuk; Shin, WonYong; Ahn, Sung Gyun; Yoon, JungHan; Kim, Yong Hoon; Cho, Yun-Hyeong; Kang, Woong Chol; Kim, Weon; Lim, Young-Hyo; Gwon, HyeonCheol; Choi, WoongGil; Lim, Do-Sun
- Issue Date
- Jan-2021
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.11, no.1, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 11
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1639
- DOI
- 10.1038/s41598-020-80319-9
- ISSN
- 2045-2322
- Abstract
- Although dual antiplatelet therapy is essential for patients who undergo percutaneous coronary interventions, the risk of bleeding remains an unsolved problem, and there is limited information on the potential relationship between genetic variants and major bleeding. We analyzed the correlations between four major single nucleotide polymorphisms (CYP2C19, ABCB1, PON1, and P2Y12 G52T polymorphisms) and clinical outcomes in 4489 patients from a prospective multicenter registry. The primary endpoint was major bleeding, defined as a Bleeding Academic Research Consortium ≥ 3 bleeding event. The allelic frequencies of ABCB1, PON1, and both individual and combined CYP2C19 variants did not differ significantly between patient groups with and without major bleeding. However, the allelic frequency of the P2Y12 variant differed significantly between the two groups. Focusing on the P2Y12 G52T variant, patients in the TT group had a significantly higher rate of major bleeding (6.4%; adjusted hazard ratio [HR] 2.51; 95% confidence interval [CI] 1.08–5.84; p = 0.033) than patients in the other groups (GG [2.9%] or GT [1.9%]). Therefore, the TT variant of the P2Y12 G52T polymorphism may be an independent predictor of major bleeding. Trial registration: NCT02707445 (https://clinicaltrials.gov/ct2/show/NCT02707445?term=02707445&draw=2&rank=1).
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1639)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.