Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Hoon | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-07-16T13:23:55Z | - |
dc.date.available | 2022-07-16T13:23:55Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164495 | - |
dc.description.abstract | Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS,but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한면역학회 | - |
dc.title | Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.4110/in.2012.12.5.217 | - |
dc.identifier.bibliographicCitation | Immune Network, v.12, no.5, pp.217 - 221 | - |
dc.relation.isPartOf | Immune Network | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 221 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001737172 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Autoimmune arthritis | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
dc.subject.keywordAuthor | Fibroblast-like synoviocytes | - |
dc.subject.keywordAuthor | Foxp3 | - |
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