Natural Killer Cell Cytolytic Function in Korean Patients with Adult-onset Still's Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jeong Ha | - |
dc.contributor.author | Kim, Hee-Sun | - |
dc.contributor.author | Lee, Jin Sook | - |
dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Jung, Kyong-Hee | - |
dc.contributor.author | Park, Yong-Wook | - |
dc.contributor.author | Yoo, Dae-Hyun | - |
dc.date.accessioned | 2022-07-16T13:27:47Z | - |
dc.date.available | 2022-07-16T13:27:47Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164538 | - |
dc.description.abstract | Objective. To investigate natural killer (NK) cell proportions, NK cell cytotoxicity, and interleukin 18 (IL-18) expression, in patients with adult-onset Still's disease (AOSD). Methods. Forty-five patients with AOSD (active = 22, inactive = 23) and 32 healthy controls were included. The proportions of NK cells among peripheral blood mononuclear cells were assessed by flow cytometry. IL-18 and IL-18-binding protein (IL-18BP) concentrations were measured by ELISA. Twenty-four patients with AOSD and 18 controls were examined for cytotoxic activity of NK cells by co-incubating NK cells with NK-sensitive K562 cells. The association of NK cell function with clinical and laboratory measures was investigated. Results. The proportions of NK cells were significantly lower in patients with active AOSD than in patients with inactive disease and controls. NK cell cytotoxic function was significantly lower in patients with AOSD than in controls. NK cell proportions and cytotoxic functions were reexamined in I 1 and 6 patients, respectively, after treatment. Low NK cell proportion and cytotoxic dysfunction were improved with clinical improvements of the patients. IL-18 and IL-18BP levels were much higher in patients with active AOSD than in controls. NK cell cytotoxic functions were consistently low and IL-18 and IL-18BP levels were constantly high in patients with AOSD, regardless of disease activity. Conclusion. Low NK cell proportion, defective cytotoxic function, and elevated IL-18 levels may be significant features of AOSD. After resolution of the acute phase, low NK cell proportion was recovered and NK cell cytolytic function was restored along with clinical improvement. These findings possibly contribute to immunologic abnormalities in AOSD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.title | Natural Killer Cell Cytolytic Function in Korean Patients with Adult-onset Still's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Dae-Hyun | - |
dc.identifier.doi | 10.3899/jrheum.111500 | - |
dc.identifier.scopusid | 2-s2.0-84867051755 | - |
dc.identifier.wosid | 000310256100015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.39, no.10, pp.2000 - 2007 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 39 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2000 | - |
dc.citation.endPage | 2007 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | MACROPHAGE ACTIVATION SYNDROME | - |
dc.subject.keywordPlus | REACTIVE HEMOPHAGOCYTIC SYNDROME | - |
dc.subject.keywordPlus | JUVENILE RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | IDIOPATHIC ARTHRITIS | - |
dc.subject.keywordPlus | PERFORIN EXPRESSION | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | CYTOKINE PROFILES | - |
dc.subject.keywordPlus | LYMPHOHISTIOCYTOSIS | - |
dc.subject.keywordPlus | INTERLEUKIN-18 | - |
dc.subject.keywordAuthor | ADULT-ONSET STILL&apos | - |
dc.subject.keywordAuthor | S DISEASE | - |
dc.subject.keywordAuthor | MACROPHAGE ACTIVATION SYNDROME | - |
dc.subject.keywordAuthor | NATURAL KILLER CELL | - |
dc.subject.keywordAuthor | INTERLEUKIN 18 | - |
dc.subject.keywordAuthor | INTERLEUKIN 18 BINDING PROTEIN | - |
dc.identifier.url | https://www.jrheum.org/content/39/10/2000 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.