Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia
- Authors
- Kim, Hawk; Lee, Kyoo-Hyung; Yoon, Sung-Soo; Sohn, Sang Kyun; Joo, Young Don; Kim, Sung Hyun; Kim, Byung Soo; Choi, Jung Hye; Kwak, Jae Youg; Hyun, Myung Soo; Bae, Sung Hwa; Shin, Ho Jin; Won, Jong Ho; Oh, Sukjoong; Lee, Won Sik; Park, Jae-Hoo; Jung, Chul Won
- Issue Date
- Oct-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Aplastic anemia; Allogeneic hematopoietic stem cell transplantation; Elderly
- Citation
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.18, no.10, pp.1500 - 1508
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Volume
- 18
- Number
- 10
- Start Page
- 1500
- End Page
- 1508
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164610
- DOI
- 10.1016/j.bbmt.2012.03.015
- ISSN
- 1083-8791
- Abstract
- Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients <= 40 years old (younger patient group [YPG]). Age at allo-HSCT <= 40 years, time from diagnosis to allo-HSCT <= 6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival. Biol Blood Marrow Transplant 18: 1500-1508 (2012)
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