Molecular Mechanisms of Carbapenem Resistance in Enterobacter cloacae Clinical Isolates from Korea and Clinical Outcome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yang soon | - |
dc.contributor.author | Choi, Heekyeong | - |
dc.contributor.author | Yum, Jong Hwa | - |
dc.contributor.author | Kang, Girung | - |
dc.contributor.author | Bae, Il Kwon | - |
dc.contributor.author | Jeong, Seok Hoon | - |
dc.contributor.author | Lee, Kyungwon | - |
dc.date.accessioned | 2022-07-16T13:44:44Z | - |
dc.date.available | 2022-07-16T13:44:44Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164663 | - |
dc.description.abstract | We investigated the molecular mechanisms of carbapenem resistance in clinical isolates of Enterobacter cloacae and their clinical characteristics. Nonreplicable E cloacae isolates were recovered from six cancer patients and one patient with liver cirrhosis at a tertiary-care hospital in Korea between 2002 and 2009. Two patients who were considered to have a true infection caused by these microorganisms have died. All isolates produced AmpC beta-lactamases, including ACT-1, ACT-2, MIR-3 and DHA-1, and CTX-M- or SHV-type extended-spectrum beta-lactamase. Two isolates produced plasmid-borne VIM-2 carbapenemase. All probes specific for bla(AmpC) genes hybridized with 1-CeuI chromosomal fragments were also recognized by a probe specific for 16S rDNA, suggesting a chromosomal location. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that a major outer membrane protein, OmpF, was absent in all isolates. PFGE of XbaI-digested DNA were considered to be unrelated. The results of our study suggest that the chromosomal AmpC beta-lactamase with impermeability in E. cloacae clinical isolates implicated in reduced carbapenem susceptibility. Although carbapenem-resistant E. cloacae isolates were isolated in a few patients in our study, the clinical outcomes were grave. Therefore, the patients colonized or infected by carbapenem-resistant E. cloacae isolates should gain attention of antibiotic therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Institute for Clinical Science | - |
dc.title | Molecular Mechanisms of Carbapenem Resistance in Enterobacter cloacae Clinical Isolates from Korea and Clinical Outcome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yang soon | - |
dc.identifier.scopusid | 2-s2.0-84868664237 | - |
dc.identifier.wosid | 000307091500006 | - |
dc.identifier.bibliographicCitation | Annals of Clinical and Laboratory Science, v.42, no.3, pp.281 - 286 | - |
dc.relation.isPartOf | Annals of Clinical and Laboratory Science | - |
dc.citation.title | Annals of Clinical and Laboratory Science | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 286 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | METALLO-BETA-LACTAMASE | - |
dc.subject.keywordPlus | KLEBSIELLA-PNEUMONIAE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | PORIN | - |
dc.subject.keywordPlus | PLASMID | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | ERTAPENEM | - |
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