Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis
DC Field | Value | Language |
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dc.contributor.author | Suk, Ki Tae | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Kim, Chang Hoon | - |
dc.contributor.author | Park, Seung Ha | - |
dc.contributor.author | Cheong, Jae Youn | - |
dc.contributor.author | Cho, Sung Won | - |
dc.contributor.author | Choi, Jong Young | - |
dc.contributor.author | Han, Kwang Hyub | - |
dc.contributor.author | Sung, Ho Taik | - |
dc.contributor.author | Hong, So Hyung | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Yoon, Jai Hoon | - |
dc.contributor.author | Kim, Yeon Soo | - |
dc.contributor.author | Baik, Gwang Ho | - |
dc.contributor.author | Kim, Jin Bong | - |
dc.date.accessioned | 2022-07-16T13:45:26Z | - |
dc.date.available | 2022-07-16T13:45:26Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164671 | - |
dc.description.abstract | Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Jai Hoon | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2012.04.031 | - |
dc.identifier.scopusid | 2-s2.0-84866024116 | - |
dc.identifier.wosid | 000308899400015 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, v.45, no.13-14, pp.1075 - 1080 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.citation.title | CLINICAL BIOCHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 13-14 | - |
dc.citation.startPage | 1075 | - |
dc.citation.endPage | 1080 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | TRANSIENT ELASTOGRAPHY FIBROSCAN | - |
dc.subject.keywordPlus | LIVER FIBROSIS | - |
dc.subject.keywordPlus | BLOOD-TESTS | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | REVERSIBILITY | - |
dc.subject.keywordPlus | ALGORITHM | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordAuthor | Liver fibrosis | - |
dc.subject.keywordAuthor | Biological markers | - |
dc.subject.keywordAuthor | Hepatic veins | - |
dc.subject.keywordAuthor | Extracellular matrix | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0009912012002160?via%3Dihub | - |
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