Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Li, Weixun | - |
dc.contributor.author | Bandyopadhyay, Jaya | - |
dc.contributor.author | Hwaang, Hyun Sook | - |
dc.contributor.author | Park, Byung-Jae | - |
dc.contributor.author | Cho, Jeong Hoon | - |
dc.contributor.author | Il Lee, Jin | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.date.accessioned | 2022-07-16T14:24:26Z | - |
dc.date.available | 2022-07-16T14:24:26Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/164994 | - |
dc.description.abstract | Thioredoxin reductase (TrxR) is a member of the pyridine nucleotide-disulfide reductase family, which mainly functions in the thioredoxin system. TrxR is found in all living organisms and exists in two major ubiquitous isoenzymes in higher eukaryotic cells; One is cytosolic and the other mitochondrial. Mitochondrial TrxR functions to protect mitochondria from oxidative stress, where reactive oxidative species are mainly generated, while cytosolic TrxR plays a role to maintain optimal oxido-reductive status in cytosol. In this study, we report differential physiological functions of these two TrxRs in C. elegans. trxr-1, the cytosolic TrxR, is highly expressed in pharynx, vulva and intestine, whereas trxr-2, the mitochondrial TrxR, is mainly expressed in pharyngeal and body wall muscles. Deficiency of the non-selenoprotein trxr-2 caused defects in longevity and delayed development under stress conditions, while deletion mutation of the selenoprotein trxr-1 resulted in interference in acidification of lysosomal compartment in intestine. Interestingly, the acidification defect of trxr-1(jh143) deletion mutant was rescued, not only by selenocystein-containing wild type TRXR-1, but also cysteine-substituted mutant TRXR-1. Both trxr-1 and trxr-2 were up-regulated when worms were challenged by environmental stress such as heat shock. These results suggest that trxr-1 and trxr-2 function differently at organismal level presumably by their differential sub-cellular localization in C. elegans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Two thioredoxin reductases, trxr-1 and trxr-2, have differential physiological roles in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1007/s10059-012-0155-6 | - |
dc.identifier.scopusid | 2-s2.0-84865321015 | - |
dc.identifier.wosid | 000307767400014 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.34, no.2, pp.209 - 218 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 209 | - |
dc.citation.endPage | 218 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001685487 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REDOX REGULATION | - |
dc.subject.keywordPlus | V-ATPASE | - |
dc.subject.keywordPlus | SELENOCYSTEINE | - |
dc.subject.keywordPlus | MITOCHONDRIAL | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INSERTION | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordAuthor | C. elegans | - |
dc.subject.keywordAuthor | longevity | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | thioredoxin reductase | - |
dc.subject.keywordAuthor | V-ATPase | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10059-012-0155-6 | - |
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