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In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1
- Authors
- Park, Chang-Hwan; Lim, Mi-Sun; Rhee, Yong-Hee; Yi, Sang-Hoon; Kim, Boe-Kyoung; Shim, Jae-Won; Kim, Yong Ho; Jung, Sung Jun; Lee, Sang-Hun
- Issue Date
- Jul-2012
- Publisher
- The Company of Biologists Ltd.
- Keywords
- Parkinson's disease; Dopamine neurons; Nurr1; Neuronal maturation; Doxycycline inducible expression system
- Citation
- Development (Cambridge), v.139, no.13, pp 2447 - 2451
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Development (Cambridge)
- Volume
- 139
- Number
- 13
- Start Page
- 2447
- End Page
- 2451
- ISSN
- 0950-1991
1477-9129
- Abstract
- Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantation purposes. Nurr1, a steroid receptor transcription factor, can overcome the limitations associated with differentiation of cultured NPCs into DA neurons. However, forced Nurr1 expression in NPC cultures generates non-neuronal and/or immature DA cells. We show here that the Nurr1 level and period of expression crucially affect the differentiation and maturation of Nurr1-induced DA neurons. Mature DA neurons were generated by manipulating Nurr1 expression patterns to resemble those in the developing midbrain.
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Related Researcher
- Jung, Sung Jun
- 서울 의과대학 (DEPARTMENT OF PHYSIOLOGY)