Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Kim, Hee Young | - |
dc.contributor.author | Cho, Sunjung | - |
dc.contributor.author | Yoo, Su-Jin | - |
dc.contributor.author | Kim, Won-Ju | - |
dc.contributor.author | Yeon, Hye Ran | - |
dc.contributor.author | Choi, Kyungho | - |
dc.contributor.author | Choi, Je-Min | - |
dc.contributor.author | Kang, Seong Wook | - |
dc.contributor.author | Lee, Won-Woo | - |
dc.date.accessioned | 2021-07-30T04:50:42Z | - |
dc.date.available | 2021-07-30T04:50:42Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1651 | - |
dc.description.abstract | Derived from a common precursor cell, the balance between Th17 and Treg cells must be maintained within immune system to prevent autoimmune diseases. IL-1β-mediated IL-1 receptor (IL-1R) signaling is essential for Th17-cell biology. Fine-tuning of IL-1R signaling is controlled by two receptors, IL-1RI and IL-RII, IL-1R accessory protein, and IL-1R antagonist. We demonstrate that the decoy receptor, IL-1RII, is important for regulating IL-17 responses in TCR-stimulated CD4+ T cells expressing functional IL-1RI via limiting IL-1β responsiveness. IL-1RII expression is regulated by NFAT via its interaction with Foxp3. The NFAT/FOXP3 complex binds to the IL-1RII promoter and is critical for its transcription. Additionally, IL-1RII expression is dysregulated in CD4+ T cells from patients with rheumatoid arthritis. Thus, differential expression of IL-1Rs on activated CD4+ T cells defines unique immunological features and a novel molecular mechanism underlies IL-1RII expression. These findings shed light on the modulatory effects of IL-1RII on Th17 responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.7554/eLife.61841 | - |
dc.identifier.scopusid | 2-s2.0-85100084986 | - |
dc.identifier.wosid | 000618849800001 | - |
dc.identifier.bibliographicCitation | ELIFE, v.10, pp.1 - 29 | - |
dc.relation.isPartOf | ELIFE | - |
dc.citation.title | ELIFE | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 29 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.subject.keywordPlus | INTERLEUKIN-1 | - |
dc.subject.keywordPlus | AUTOIMMUNE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | NFAT | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | Foxp3 | - |
dc.subject.keywordAuthor | IL-1 receptor | - |
dc.subject.keywordAuthor | IL-1β | - |
dc.subject.keywordAuthor | NFAT | - |
dc.subject.keywordAuthor | Rheumatoid arthritis (RA) | - |
dc.subject.keywordAuthor | Th17 | - |
dc.identifier.url | https://elifesciences.org/articles/61841 | - |
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