A single nucleotide polymorphism in the phospholipase D1 gene is associated with risk of non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Ahn, Myung-Ju | - |
dc.contributor.author | Park, Shin-Young | - |
dc.contributor.author | Kim, Won Kyu | - |
dc.contributor.author | Cho, Ju Hwan | - |
dc.contributor.author | Chang, Brian Junho | - |
dc.contributor.author | Kim, Dong Jo | - |
dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Park, Keunchil | - |
dc.contributor.author | Han, Joong-Soo | - |
dc.date.accessioned | 2022-07-16T15:04:02Z | - |
dc.date.available | 2022-07-16T15:04:02Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1550-9702 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165366 | - |
dc.description.abstract | Phospholipase D (PLD) has an important role in various biological functions including vesicular transport, endocytosis, exocytosis, cell migration, and mitosis. These cellular biological processes are deregulated in the development of various human tumors. In order to explore the relationship between the PLD1 gene and risk of non-small cell lung cancer (NSCLC), single nucleotide polymorphisms (SNP) in the PLD1 exon region were surveyed in 211 NSCLC patients and 205 normal controls. In this study, we identified six SNPs at exon 23 in the PLD1 gene. Among the six SNPs, the most notable was a heterozygous A to C transition at nucleotide 2698 (A2698C, p<0.001). In addition, the genotype frequencies of A2744C (AC+CC) and A2756C (AC+CC) were associated with gender (female, A2744C and A2756C: p=0.071) in NSCLC patients. Interestingly, although the SNP A2698C did not cause change in amino acid, correlation between odd ratio of NSCLC patients and the SNP A2698C was observed to be statistically significant. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Master Publishing Group | - |
dc.title | A single nucleotide polymorphism in the phospholipase D1 gene is associated with risk of non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Won Kyu | - |
dc.contributor.affiliatedAuthor | Han, Joong-Soo | - |
dc.identifier.scopusid | 2-s2.0-84865373630 | - |
dc.identifier.bibliographicCitation | International Journal of Biomedical Science, v.8, no.2, pp.121 - 128 | - |
dc.relation.isPartOf | International Journal of Biomedical Science | - |
dc.citation.title | International Journal of Biomedical Science | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 121 | - |
dc.citation.endPage | 128 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | phospholipase D1 | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | amino acid substitution | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cancer risk | - |
dc.subject.keywordPlus | cancer susceptibility | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | exon | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene frequency | - |
dc.subject.keywordPlus | genetic association | - |
dc.subject.keywordPlus | genetic susceptibility | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human tissue | - |
dc.subject.keywordPlus | lung non small cell cancer | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mutational analysis | - |
dc.subject.keywordPlus | mutator gene | - |
dc.subject.keywordPlus | phospholipase D1 gene | - |
dc.subject.keywordPlus | sex difference | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | DGGE | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | NSCLC | - |
dc.subject.keywordAuthor | Phospholipase D | - |
dc.subject.keywordAuthor | Single nucleotide polymorphism | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614861/pdf/IJBS-8-121.pdf | - |
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