Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections
DC Field | Value | Language |
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dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Ko, Joo Yeon | - |
dc.contributor.author | Park, Chan Kum | - |
dc.date.accessioned | 2022-07-16T15:09:11Z | - |
dc.date.available | 2022-07-16T15:09:11Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 0303-6987 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165418 | - |
dc.description.abstract | The non-specific clinical findings and variable histopathological features of cutaneous tuberculosis and non-tuberculous mycobacterial infections often make it difficult to establish a diagnosis and initiate appropriate therapy. We investigated 25 patients diagnosed with mycobacterial infections of the skin in Hanyang University Hospital between 2001 and 2011. Skin biopsy specimens were re-evaluated by various histopathological criteria and molecular studies. To identify the mycobacteria, we performed staining for acid-fast bacilli and also completed polymerase chain reaction analysis. The non-tuberculous mycobacterium species were identified by genetic sequencing of formalin-fixed, paraffin-embedded tissues. Immunocompromised status was more frequent in non-tuberculous mycobacterial infections than in tuberculosis (p = 0.017) while disease duration was longer in tuberculosis (p = 0.026). Microscopically, neutrophil infiltration, interstitial granuloma, small vessel proliferation and increased numbers of bacilli were found to be associated with non-tuberculous mycobacterial infections (all p < 0.05). In contrast, giant cells, plasma cells, tuberculoid granulomas and necrosis were associated with tuberculosis (all p < 0.05). There were no species-specific histopathological findings in non-tuberculous mycobacterial infections. The significant histopathological differences between cutaneous tuberculous and non-tuberculous mycobacterial infections are helpful in considering differential diagnoses. In addition, molecular techniques together with clinico-pathological findings may assist in making accurate diagnoses of cutaneous non-tuberculous mycobacterial infections. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Histopathological spectrum of cutaneous tuberculosis and non-tuberculous mycobacterial infections | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.contributor.affiliatedAuthor | Ko, Joo Yeon | - |
dc.identifier.doi | 10.1111/j.1600-0560.2012.01903.x | - |
dc.identifier.scopusid | 2-s2.0-84861591722 | - |
dc.identifier.wosid | 000304343600005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CUTANEOUS PATHOLOGY, v.39, no.6, pp.582 - 595 | - |
dc.relation.isPartOf | JOURNAL OF CUTANEOUS PATHOLOGY | - |
dc.citation.title | JOURNAL OF CUTANEOUS PATHOLOGY | - |
dc.citation.volume | 39 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 582 | - |
dc.citation.endPage | 595 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | LABORATORY DIAGNOSIS | - |
dc.subject.keywordPlus | GROWING MYCOBACTERIA | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | non-tuberculous mycobacterium | - |
dc.subject.keywordAuthor | infection | - |
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