The Effects of 5-HT4 Receptor Agonist, Mosapride Citrate, on Visceral Hypersensitivity in a Rat Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae Woong | - |
dc.contributor.author | Sung, Ki Woon | - |
dc.contributor.author | Lee, Oh Young | - |
dc.contributor.author | Lee, Seo Eun | - |
dc.contributor.author | Sohn, Chong Il | - |
dc.date.accessioned | 2022-07-16T15:09:16Z | - |
dc.date.available | 2022-07-16T15:09:16Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165419 | - |
dc.description.abstract | Mosapride citrate is known to affect gastric motility. However, whether mosapride citrate has any effect on visceral pain in the colon or rectum is not certain. The aim of this study was to assess the effects of mosapride citrate on visceral pain in a rat visceral hypersensitivity model. The perception of visceral pain was evaluated by the visceromotor response to colorectal distension observed on electromyographs of the abdominal musculature in urethane-anesthetized rats. Visceral hypersensitivity was induced by the intrarectal instillation of 4% acetic acid or 1.5% zymosan. Mosapride citrate was administered intraperitoneally 3 h later. VMRs to CRD were recorded prior to the instillation of acetic acid or zymosan and before and after mosapride citrate treatment. The intracolonic instillation of acetic acid resulted in a significant increase in VMRs of the abdominal muscles to CRD, compared with the pretreatment state (174 +/- A 24%, P < 0.05). The intracolonic instillation of zymosan resulted in a significant increase in VMRs of the abdominal muscles to CRD, compared with the pretreatment state (144 +/- A 9%, P < 0.05). Intraperitoneal injection of mosapride citrate resulted in a significant reduction in the VMRs to CRD in an acetic acid-induced visceral hypersensitivity rat model (61 +/- A 9%, P < 0.05). The intraperitoneal injection of mosapride citrate also resulted in a significant reduction in the VMRs to CRD in a zymosan-induced visceral hypersensitivity rat model (67 +/- A 9%, P < 0.05). Mosapride citrate diminished visceral pain in rats. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | The Effects of 5-HT4 Receptor Agonist, Mosapride Citrate, on Visceral Hypersensitivity in a Rat Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Oh Young | - |
dc.identifier.doi | 10.1007/s10620-012-2101-z | - |
dc.identifier.scopusid | 2-s2.0-84864184418 | - |
dc.identifier.wosid | 000304396700014 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, v.57, no.6, pp.1517 - 1524 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.title | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1517 | - |
dc.citation.endPage | 1524 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | IRRITABLE-BOWEL-SYNDROME | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INHIBITORY CONTROLS | - |
dc.subject.keywordPlus | ABDOMINAL-PAIN | - |
dc.subject.keywordPlus | COLORECTAL DISTENSION | - |
dc.subject.keywordPlus | RECTAL DISTENSION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | TEGASEROD | - |
dc.subject.keywordAuthor | Mosapride citrate | - |
dc.subject.keywordAuthor | Colorectal distension | - |
dc.subject.keywordAuthor | Visceral hypersensitivity | - |
dc.subject.keywordAuthor | Irritable bowel | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10620-012-2101-z | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.