Association between Serum Stromal Cell-Derived Factor-1 alpha and Long-Term Outcome of Acute Ischemic Stroke
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Seo | - |
dc.contributor.author | Baek, Wonki | - |
dc.contributor.author | Kim, Mi K. | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Lee, Kyu-Yong | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Chang, Dae-Il | - |
dc.contributor.author | Koh, Seong-Ho | - |
dc.date.accessioned | 2022-07-16T15:13:18Z | - |
dc.date.available | 2022-07-16T15:13:18Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 0014-3022 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165466 | - |
dc.description.abstract | Background: Stromal cell-derived factor-1 alpha (SDF-1 alpha) provides neurotrophic support to neurons. In this prospective study, we investigated the association between SDF-1 alpha and long-term outcome in patients with acute ischemic stroke. Methods: This study included 104 patients with first-ever ischemic stroke, identified within 24 h of symptom onset. Serum samples were collected immediately after admission and 3 months thereafter, as well as from age- and sex-matched normal controls. The correlation between acute-stage serum SDF-1 alpha and stroke severity were analyzed. Finally, the relationship between serum SDF-1 alpha and long-term outcome was evaluated by multivariate analysis. Results: Serum SDF-1 alpha levels were only higher in acute-stage stroke patients compared with the normal control group (p = 0.011). The serum SDF-1 alpha level was increased in proportion to infarct volume (r = 0.220, p = 0.025) and initial National Institutes of Health Stroke Scale score (r = 0.275, p = 0.005). After adjustment for covariates, a high initial serum SDF-1 alpha level (OR 1.167, p = 0.023) or second and third tertiles of SDF-1 alpha level compared to first tertile (OR 4.644, p = 0.044 and OR 9.396, p = 0.025, respectively) were significantly associated with a favorable long-term outcome. Conclusions: This prospective study demonstrated a correlation between serum SDF-1 alpha and favorable long-term outcome in patients with acute ischemic stroke. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.title | Association between Serum Stromal Cell-Derived Factor-1 alpha and Long-Term Outcome of Acute Ischemic Stroke | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young Seo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Young | - |
dc.contributor.affiliatedAuthor | Lee, Kyu-Yong | - |
dc.contributor.affiliatedAuthor | Lee, Young Joo | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Koh, Seong-Ho | - |
dc.identifier.doi | 10.1159/000335351 | - |
dc.identifier.scopusid | 2-s2.0-84861217368 | - |
dc.identifier.wosid | 000305875300008 | - |
dc.identifier.bibliographicCitation | EUROPEAN NEUROLOGY, v.67, no.6, pp.363 - 369 | - |
dc.relation.isPartOf | EUROPEAN NEUROLOGY | - |
dc.citation.title | EUROPEAN NEUROLOGY | - |
dc.citation.volume | 67 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 363 | - |
dc.citation.endPage | 369 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | ADULT BRAIN | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | SDF-1 | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordAuthor | Stromal cell-derived factor-1 alpha | - |
dc.subject.keywordAuthor | Ischemic stroke | - |
dc.subject.keywordAuthor | Stroke outcome | - |
dc.subject.keywordAuthor | Neurotrophic effect | - |
dc.identifier.url | https://www.karger.com/Article/FullText/335351 | - |
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