TNF-alpha genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Shin, Dong Ho | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Kim, Youn-Seup | - |
dc.contributor.author | Park, Jae-Seuk | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.date.accessioned | 2022-07-16T15:30:46Z | - |
dc.date.available | 2022-07-16T15:30:46Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165683 | - |
dc.description.abstract | Background: While the mechanisms underlying the development of druginduced liver injury are not clear, there is evidence to suggest that tumor necrosis factor-a (TNF-a) plays an important role in drug-or drug metabolite- induced immune responses. We hypothesized that polymorphisms in the TNF-a gene are associated with anti-tuberculosis drug (ATD)-induced hepatitis. Methods: Patients who suffered from ATD-induced hepatitis were enrolled in the study. ATD-induced hepatitis was defined as an increase in liver transaminase levels that were more than three times the upper limit of normal. ATD-tolerant patients were used as a control. Patients were treated with first line ATD therapies including isoniazid, rifampicin, ethambutol, and pyrazinamide. We compared the genotype frequencies of the TNF-a polymorphism -308G/ A in 77 patients with ATD-induced hepatitis and 229 ATD-tolerant patients. Results: The frequency of carrying the variant allele (AG or AA) was significantly higher in patients with ATD-induced hepatitis compared with ATD-tolerant patients [26.0% vs. 15.3%, P = 0.034, OR (95% CI) = 1.94 (1.04-3.64)] and the frequency of the A allele was significantly different between the two groups [0.143 vs. 0.079, P = 0.018, OR (95% CI) = 1.95 (1.11-3.44)]. Conclusion: These results reveal that the TNF-a genetic polymorphism -308G/ A is significantly associated with ATD-induced hepatitis. This genetic variant may be a risk factor for ATD-induced hepatitis in individuals from Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | TNF-alpha genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.1111/j.1478-3231.2011.02697.x | - |
dc.identifier.scopusid | 2-s2.0-84859440606 | - |
dc.identifier.wosid | 000302468700015 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, v.32, no.5, pp.809 - 814 | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.citation.title | LIVER INTERNATIONAL | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 809 | - |
dc.citation.endPage | 814 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INDUCED LIVER-INJURY | - |
dc.subject.keywordPlus | S-TRANSFERASE M1 | - |
dc.subject.keywordPlus | INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | CARBON-TETRACHLORIDE | - |
dc.subject.keywordPlus | NULL MUTATIONS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordAuthor | antituberculosis drugs | - |
dc.subject.keywordAuthor | genetic polymorphism | - |
dc.subject.keywordAuthor | hepatitis | - |
dc.subject.keywordAuthor | tumour necrosis factor-a | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02697.x | - |
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