Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa
DC Field | Value | Language |
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dc.contributor.author | Park, Chan Jin | - |
dc.contributor.author | Nah, Won Heum | - |
dc.contributor.author | Lee, Jae-Eun | - |
dc.contributor.author | Yoon Sik | - |
dc.contributor.author | Gye, Myung Chan | - |
dc.date.accessioned | 2022-07-16T15:33:44Z | - |
dc.date.available | 2022-07-16T15:33:44Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0303-4569 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165714 | - |
dc.description.abstract | Parabens have been shown to affect male rodent reproductive parameters, including testosterone levels and sperm production. In this study, we examined the effect of long-term exposure to butyl paraben (BP) on rat epididymal sperm DNA methylation. Adult male rats were exposed to BP (0, 10, 100 and 1000 mg kg-1 per day) according to OECD TG407 for a repeated 28-day oral toxicity study. Sperm DNA methylation was examined by differential display random amplification of polymorphic DNA (RAPD) following methylation-specific restriction digestion of DNA. Among the 57 RAPD amplicons, six were methylation specific. Of these, five amplicons increased by 1.4- to 3.8-fold in epididymal sperm DNA at testing dose of BP. This indicates that BP can cause DNA hypermethylation in germ cells from the mitotic through post-meiotic stage in adult rat testes. To our knowledge, this is the first report on the epigenetic modification of sperm DNA by parabens. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Butyl paraben-induced changes in DNA methylation in rat epididymal spermatozoa | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gye, Myung Chan | - |
dc.identifier.doi | 10.1111/j.1439-0272.2011.01162.x | - |
dc.identifier.scopusid | 2-s2.0-84861508113 | - |
dc.identifier.wosid | 000304439300024 | - |
dc.identifier.bibliographicCitation | ANDROLOGIA, v.44, pp.187 - 193 | - |
dc.relation.isPartOf | ANDROLOGIA | - |
dc.citation.title | ANDROLOGIA | - |
dc.citation.volume | 44 | - |
dc.citation.startPage | 187 | - |
dc.citation.endPage | 193 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Andrology | - |
dc.subject.keywordPlus | MALE REPRODUCTIVE-SYSTEM | - |
dc.subject.keywordPlus | MALE GERM-CELLS | - |
dc.subject.keywordPlus | ENDOCRINE DISRUPTORS | - |
dc.subject.keywordPlus | MOUSE EMBRYO | - |
dc.subject.keywordPlus | TESTIS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | METHYLTRANSFERASE | - |
dc.subject.keywordPlus | HYPOMETHYLATION | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordAuthor | Butyl paraben | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.subject.keywordAuthor | epididymal spermatozoa | - |
dc.subject.keywordAuthor | rat | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0272.2011.01162.x | - |
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