New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Manavalan, Arulmani | - |
dc.contributor.author | Feng, Lin | - |
dc.contributor.author | Sze, Siu Kwan | - |
dc.contributor.author | Hu, Jiang-Miao | - |
dc.contributor.author | Heese, Klaus | - |
dc.date.accessioned | 2022-07-16T15:53:50Z | - |
dc.date.available | 2022-07-16T15:53:50Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1874-3919 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165839 | - |
dc.description.abstract | Gastrodia elata (tianma) is a traditional Chinese herbal medicine (TCM) often used for the treatment of cerebrovascular diseases. In this study, we investigated the effects of tianma on the brain protein metabolism by quantitative proteomics to gain evidence for a direct relationship between tianma treatment and brain functions. One-year-old rats were treated with tianma (similar to 2.5 g/kg/day) for 3 months and the brain tissue proteome was analyzed by using the iTRAQ (isobaric tag for relative and absolute quantification) technology. According to our results, the long-term treatment with tianma could modulate the brain protein metabolism at the proteome level by down-regulating the expressions of various proteins, such as Gnaol and Dctn2, which are related to neuronal growth cone control and synaptic activities. In addition, tianma treatment also induced the up-regulation of molecular chaperons and proteins related to the misfolded protein response, like Anxa5, and also other proteins involved in Huntington's disease (HD) (e.g. Pacsin1 and Arf3). Concluding, tianma could eventually contribute to activities related to synaptic plasticity and neurorestorative processes and thus might be a novel candidate agent for the treatment of neurodegenerative diseases by regulating the brain proteome. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier B.V. | - |
dc.title | New insights into the brain protein metabolism of Gastrodia elata-treated rats by quantitative proteomics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Heese, Klaus | - |
dc.identifier.doi | 10.1016/j.jprot.2012.02.029 | - |
dc.identifier.scopusid | 2-s2.0-84862805283 | - |
dc.identifier.wosid | 000303974800017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PROTEOMICS, v.75, no.8, pp.2468 - 2479 | - |
dc.relation.isPartOf | JOURNAL OF PROTEOMICS | - |
dc.citation.title | JOURNAL OF PROTEOMICS | - |
dc.citation.volume | 75 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2468 | - |
dc.citation.endPage | 2479 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.subject.keywordPlus | DEPENDENT BULK ENDOCYTOSIS | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION FACTORS | - |
dc.subject.keywordPlus | HUNTINGTONS-DISEASE | - |
dc.subject.keywordPlus | ETHER FRACTION | - |
dc.subject.keywordPlus | EXPRESSION PATTERNS | - |
dc.subject.keywordPlus | SYNAPTIC VESICLES | - |
dc.subject.keywordPlus | METHANOL EXTRACTS | - |
dc.subject.keywordPlus | CHINESE MEDICINE | - |
dc.subject.keywordPlus | VANILLYL ALCOHOL | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Tianma | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
dc.subject.keywordAuthor | Metabolism | - |
dc.subject.keywordAuthor | Signaling | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.