Biphasic Stress Response in the Soleus during Reloading after Hind Limb Unloading
DC Field | Value | Language |
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dc.contributor.author | Lawler, John M. | - |
dc.contributor.author | Kwak, Hyo-Bum | - |
dc.contributor.author | Kim, Jong-Hee | - |
dc.contributor.author | Lee, Yang | - |
dc.contributor.author | Hord, Jeffrey M. | - |
dc.contributor.author | Martinez, Daniel A. | - |
dc.date.accessioned | 2022-07-16T15:54:21Z | - |
dc.date.available | 2022-07-16T15:54:21Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0195-9131 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165844 | - |
dc.description.abstract | LAWLER, J. M., H.-B. KWAK, J.-H. KIM, Y. LEE, J. M. HORD, and D. A. MARTINEZ. Biphasic Stress Response in the Soleus during Reloading after Hind Limb Unloading. Med. Sci. Sports Exerc., Vol. 44, No. 4, pp. 600-609,2012. Introduction: Extreme disuse and spaceflight elicit rapid skeletal muscle atrophy, accompanied by elevated proinflammatory signaling and impaired stress response proteins (e.g., heat shock proteins (HSP), insulin-like growth factor 1 (IGF-1)). Recovery of muscle mass is delayed during the early stage of reloading after prolonged unloading, with a concomitant impairment of HSP70 and IGF-1. We postulated that proinflammatory signaling and stress response alterations would characterize early and late phases of signaling during reloading. Methods: Twenty-four adult SD rats were divided into the following groups: controls, 28 d of hind limb unloading (HU), HU + early (7 d) reloading (HU-R7), and HU + late (28 d) reloading (HU-R28). Results: Soleus mass decreased (-55%) with HU and remained depressed (-41%) at HU-R7. Nuclear factor KB activation and oxidative stress were elevated with HU and remained high during reloading. HU elevated inducible nitric oxide synthase and returned to baseline during reloading, whereas 3-nitrotyrosine did not increase with HU and peaked at HU-R7. HU depressed levels of HSP25 phosphorylation at Ser82 and IGF-1. Although p-HSP25 and Akt phosphorylation (Ser473) recovered during early reloading, HSP70, heat shock factor I, and IGF-I remained depressed. HSP70, heat shock factor 1, and IGF-1 recovered, whereas p-Akt and 3-nitrotyrosine decreased to control levels at HU-R28. Conclusions: Reloading elicited an early phase characterized by elevated nuclear factor kappa B activation, 3-nitrotyrosine, p-HSP25, and p-Akt levels and a delayed phase with recovery of HSP70, IGF-1, and muscle mass. We conclude that the reloading phenotype in skeletal muscle is expressed in two distinct phases related to (a) pro-inflammatory signaling and (b) muscle mass recovery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Biphasic Stress Response in the Soleus during Reloading after Hind Limb Unloading | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hee | - |
dc.identifier.doi | 10.1249/MSS.0b013e31823ab37a | - |
dc.identifier.scopusid | 2-s2.0-84858701892 | - |
dc.identifier.wosid | 000301897200006 | - |
dc.identifier.bibliographicCitation | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.44, no.4, pp.600 - 609 | - |
dc.relation.isPartOf | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE | - |
dc.citation.title | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 600 | - |
dc.citation.endPage | 609 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Sport Sciences | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE ATROPHY | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | HEAT-SHOCK PROTEINS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ACUTE EXERCISE | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | MUSCLE ATROPHY | - |
dc.subject.keywordAuthor | SPACEFLIGHT | - |
dc.subject.keywordAuthor | nNOS | - |
dc.subject.keywordAuthor | HEAT SHOCK PROTEINS | - |
dc.identifier.url | https://journals.lww.com/acsm-msse/Fulltext/2012/04000/Biphasic_Stress_Response_in_the_Soleus_during.6.aspx | - |
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