Time-dependent increase in aqueous solubility caused by the gradual disruption of hydrophobic aggregation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Seo-Hyun | - |
dc.contributor.author | Ryu, Jungju | - |
dc.contributor.author | Sohn, Daewon | - |
dc.contributor.author | Lee, Hyung-Il | - |
dc.date.accessioned | 2022-07-16T15:58:56Z | - |
dc.date.available | 2022-07-16T15:58:56Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1759-9954 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165908 | - |
dc.description.abstract | We report the preparation of a thermoresponsive polymer whose solubility in water can be controlled simply by time elapse. Most importantly, we showed that the gradual disruption of hydrophobic aggregation originated from strong pi-pi stacking between side chain triazole rings resulting in an increase in the cloud point. As time progressed, hydrogen bonds between one of the triazole ring nitrogen atoms and water molecules became dominant. This caused disruption of the hydrophobic domains by breaking pi-pi stacking between the triazole rings, leading to a thermodynamically stable hydration state. The gradual disruption of hydrophobic aggregation induced a time-dependent increase in the apparent cloud point. This time-dependent increase in aqueous solubility was not driven by hydrolytic degradation of ester linkages. This behavior was carefully characterized using a number of techniques, including percent transmission analysis, UV-Vis spectroscopy and H-1-NMR spectroscopy, and dynamic light scattering (DLS) measurements, all supporting our hypothesis. This macromolecule, which offers tailored control over aqueous solubility, may be a unique potential platform for drug delivery scaffolds where the release of encapsulated molecules is controlled simply by time. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Time-dependent increase in aqueous solubility caused by the gradual disruption of hydrophobic aggregation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Daewon | - |
dc.identifier.doi | 10.1039/c2py00559j | - |
dc.identifier.scopusid | 2-s2.0-84863256764 | - |
dc.identifier.wosid | 000301199600024 | - |
dc.identifier.bibliographicCitation | POLYMER CHEMISTRY, v.3, no.4, pp.1002 - 1006 | - |
dc.relation.isPartOf | POLYMER CHEMISTRY | - |
dc.citation.title | POLYMER CHEMISTRY | - |
dc.citation.volume | 3 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1002 | - |
dc.citation.endPage | 1006 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | TRANSFER RADICAL POLYMERIZATION | - |
dc.subject.keywordPlus | 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2012/PY/c2py00559j | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.