Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor delta agonists as potent anti-obesity agents in vivo
DC Field | Value | Language |
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dc.contributor.author | Ham, Jungyeob | - |
dc.contributor.author | Hwang, Hoosang | - |
dc.contributor.author | Kim, Euno | - |
dc.contributor.author | Kim, Jeong-ah | - |
dc.contributor.author | Cho, Sung Jin | - |
dc.contributor.author | Ko, Jaeyoung | - |
dc.contributor.author | Lee, Woojin | - |
dc.contributor.author | Lee, Jaehwan | - |
dc.contributor.author | Holla, Harish | - |
dc.contributor.author | Tak, Jun gae | - |
dc.date.accessioned | 2022-07-16T16:10:48Z | - |
dc.date.available | 2022-07-16T16:10:48Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166017 | - |
dc.description.abstract | We have discovered and demonstrated the in vitro and in vivo PPAR delta-selective activity of novel Y-shaped agonists. These compounds activated hPPAR delta with EC50 values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the most potent and most selective hPPAR delta agonists with 10(4)-fold selectivity over the other two subtypes, namely, hPPAR alpha and hPPAR gamma. The PPAR delta ligands 10a, 11e and 11f showed good bioavailability and in vivo efficacy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor delta agonists as potent anti-obesity agents in vivo | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Tak, Jun gae | - |
dc.identifier.doi | 10.1016/j.ejmech.2012.03.055 | - |
dc.identifier.scopusid | 2-s2.0-84861584756 | - |
dc.identifier.wosid | 000305863100020 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.53, pp.190 - 202 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 53 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 202 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordAuthor | Anti-obesity | - |
dc.subject.keywordAuthor | GW501516 | - |
dc.subject.keywordAuthor | Marine natural products | - |
dc.subject.keywordAuthor | Nuclear receptors | - |
dc.subject.keywordAuthor | PPARδ | - |
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