Experimental validation of the solvent-gradient simulated moving bed process for optimal separation of phenylalanine and tryptophan
DC Field | Value | Language |
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dc.contributor.author | Nam, Hee-Geun | - |
dc.contributor.author | Jo, Se-Hee | - |
dc.contributor.author | Park, Chanhun | - |
dc.contributor.author | Mun, Sungyong | - |
dc.date.accessioned | 2022-07-16T16:19:43Z | - |
dc.date.available | 2022-07-16T16:19:43Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1359-5113 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166123 | - |
dc.description.abstract | A solvent-gradient simulated moving bed (SG-SMB) process for separation of two useful amino acids, phenylalanine and tryptophan, has been studied in previous researches, which confirmed that the SG-SMB outperformed the corresponding isocratic SMB for the same separation task. However, all of the previous studies on the SG-SMB for separation of the two amino acids have been limited to process simulation and optimization, including some batch-chromatography tests. The experimental validation of such an SG-SMB process was attempted in this article. This task began by assembling the experimental unit of the SG-SMB process. Its operating conditions were determined from the SG-SMB optimization tool based on genetic algorithm, in which the mass-transfer parameters as well as the adsorption isotherm parameters of the feed components (two amino acids) were entered as the mathematical models expressed as a function of liquid-phase composition (i.e., modifier concentration in the liquid phase). Based on the determined operating conditions, the relevant SG-SMB experiment was conducted until a cyclic steady-state was reached. The assay of all the resultant product samples verified that the SG-SMB separation of interest was performed successfully as designed. The experimental data were also found to agree closely with the model predictions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Experimental validation of the solvent-gradient simulated moving bed process for optimal separation of phenylalanine and tryptophan | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Mun, Sungyong | - |
dc.identifier.doi | 10.1016/j.procbio.2011.11.011 | - |
dc.identifier.scopusid | 2-s2.0-84856225721 | - |
dc.identifier.wosid | 000300868700009 | - |
dc.identifier.bibliographicCitation | PROCESS BIOCHEMISTRY, v.47, no.3, pp.401 - 409 | - |
dc.relation.isPartOf | PROCESS BIOCHEMISTRY | - |
dc.citation.title | PROCESS BIOCHEMISTRY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 401 | - |
dc.citation.endPage | 409 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | STANDING-WAVE DESIGN | - |
dc.subject.keywordPlus | MASS-TRANSFER | - |
dc.subject.keywordPlus | POLY-4-VINYLPYRIDINE CHROMATOGRAPHY | - |
dc.subject.keywordPlus | MULTIOBJECTIVE OPTIMIZATION | - |
dc.subject.keywordPlus | GENETIC ALGORITHM | - |
dc.subject.keywordPlus | ETHANOL CONTENT | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | ISOTHERMS | - |
dc.subject.keywordPlus | OPERATION | - |
dc.subject.keywordAuthor | Phenylalanine | - |
dc.subject.keywordAuthor | Tryptophan | - |
dc.subject.keywordAuthor | Poly-4-vinylpyridine (PVP) | - |
dc.subject.keywordAuthor | Amino acid separation | - |
dc.subject.keywordAuthor | Simulated moving bed | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1359511311004089?via%3Dihub | - |
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