CNP-1 (ARRD-17), a Novel Substrate of Calcineurin, Is Critical for Modulation of Egg-Laying and Locomotion in Response to Food and Lysine Sensation in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Jee, Changhoon | - |
dc.contributor.author | Choi, Tae-Woo | - |
dc.contributor.author | Kalichamy, Karunambigai | - |
dc.contributor.author | Yee, Jong Zin | - |
dc.contributor.author | Song, Hyun-Ok | - |
dc.contributor.author | Ji, Yon Ju | - |
dc.contributor.author | Lee, Jungsoo | - |
dc.contributor.author | Lee, Jin Il | - |
dc.contributor.author | L'Etoile, Noelle D. | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.date.accessioned | 2022-07-16T16:33:46Z | - |
dc.date.available | 2022-07-16T16:33:46Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166174 | - |
dc.description.abstract | Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase involved in calcium signaling pathways. In Caenorhabditis elegans, the loss of calcineurin activity causes pleiotropic defects including hyperadaptation of sensory neurons, hypersensation to thermal difference and hyper-egg-laying when worms are refed after starvation. In this study, we report on arrd-17 as calcineurin-interacting protein-1 (cnp-1), which is a novel molecular target of calcineurin. CNP-1 interacts with the catalytic domain of the C. elegans calcineurin A subunit, TAX-6, in a yeast two-hybrid assay and is dephosphorylated by TAX-6 in vitro. cnp-1 is expressed in ASK, ADL, ASH and ASJ sensory neurons as TAX-6. It acts downstream of tax-6 in regulation of locomotion and egg-laying after starvation, ASH sensory neuron adaptation and lysine chemotaxis, that is known to be mediated by ASK neurons. Altogether, our biochemical and genetic evidence indicates that CNP-1 is a direct target of calcineurin and required in stimulated egg-laying and locomotion after starvation, adaptation to hyperosmolarity and attraction to lysine, which is modulated by calcineurin. We suggest that the phosphorylation status of CNP-1 plays an important role in regulation of refed stimulating behaviors after starvation and attraction to amino acid, which provides valuable nutritious information. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.title | CNP-1 (ARRD-17), a Novel Substrate of Calcineurin, Is Critical for Modulation of Egg-Laying and Locomotion in Response to Food and Lysine Sensation in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1016/j.jmb.2012.01.012 | - |
dc.identifier.scopusid | 2-s2.0-84862798422 | - |
dc.identifier.wosid | 000301805800004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.417, no.3, pp.165 - 178 | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 417 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | UP-REGULATED PROTEIN-1 | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | THIOREDOXIN FUNCTION | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURES | - |
dc.subject.keywordPlus | CELL-FUNCTION | - |
dc.subject.keywordPlus | DOCKING SITE | - |
dc.subject.keywordPlus | ARRESTIN | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | ATTRACTANTS | - |
dc.subject.keywordAuthor | calcineurin | - |
dc.subject.keywordAuthor | CNP-1 | - |
dc.subject.keywordAuthor | ARRD-17 | - |
dc.subject.keywordAuthor | ASK | - |
dc.subject.keywordAuthor | ASH | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022283612000666?via%3Dihub | - |
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